| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Brains are constituted of the various types of neurons and each neuron responds to the various stimuli heterogeneously. While it enables to enlarge the capacity for memory, it makes us difficult to analyze which cells should be focused. In this project I tried to label and analyze the cell populations which showed homogeneous activities by using Drosophila olfactory memory as a model. I focused on CREB, an essential transcriptional factor for long-term memory, to divide the mushroom body (MB) neurons into two populations which was olfactory memory center in insects in a CRE-dependent manner. We found that the activity balance between CRE-positive and -negative MB gamma neurons could change the learning efficiency of aversive and appetitive memory, and they inhibited mutually.
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