| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The neuromuscular junction (NMJ) is a synapse that connects the spinal motor and skeletal muscle fiber. Factors involved in NMJ morphogenesis and maturation has not been yet elucidated, and the mechanism of the known factors in NMJ has not been fully elucidated.
In this study, we investigated to identify growth factors involved in NMJ formation and signal transduction pathways downstream of them. We showed that the secretion factors such as Rspo2 and FGF18 are required for NMJ function to activate MuSK activation and/or AChR. We also showed that these factors are involved in the maturation and maintenance of NMJ. In addition, we suggested that IGF, TGFbeta and hedgehog may be involved in NMJ formation.
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