| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In order to elucidate the molecular mechanism of neurogenesis in adult brain and to develop artificial control method, I focused on DNA demethylation factor TET1 which controls DNA methylation, and comprehensive gene expression analysis of neural stem cells (NSCs) derived from adult brain, and cell biological analysis were performed. As a result, while TET1 has a common self-renewal control mechanism with TET2, the presence of REV-ERBβ as a TET1-specific downstream regulatory factor was revealed. Furthermore, molecular biological analysis of REV-ERBβ revealed that REV-ERBβ is involved in the regulation of undifferentiation and neuronal differentiation of adult NSCs, and it is possible to control artificial neurogenesis by ligands of REV-ERBβ was also suggested.
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