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Dynamic information processing in neuronal axons

Research Project

Project/Area Number 15K06722
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionKyoto University (2017)
Doshisha University (2015-2016)

Principal Investigator

Kawaguchi Shin-ya  京都大学, 産官学連携本部, 特定准教授 (00378530)

Co-Investigator(Renkei-kenkyūsha) SAKABA Takeshi  同志社大学, 脳科学研究科, 教授 (80609511)
Research Collaborator DIAZ-ROJAS Francois  同志社大学, 脳科学研究科, 大学院生
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords軸索終末 / シナプス / パッチクランプ / 小脳 / Ca緩衝 / GABA-A受容体 / 短期シナプス可塑性 / 伝達物質放出 / 軸索 / シナプス可塑性 / 伝達物質受容体 / 短期促通 / シナプス前部 / 受容体 / シナプス伝達 / 活動電位 / イメージング / 膜電位
Outline of Final Research Achievements

Physiology of an axon and its terminals in the central nervous system remains elusive because of the difficulty to analyze the small size of structures. In this project, we clarified the dynamic regulation mechanism of information processing in the axon and terminals by using the direct patch-clamp recording technique together with local activation of transmitter by a spot laser illumination method. Specifically, we analyzed dynamic regulation mechanisms to control transmitter release from terminals of Purkinje cells and granule cells which mediate fine motor control.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Int'l Joint Research] パリ デカルト大学/CNRS(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] CNRS(フランス)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression.2018

    • Author(s)
      Yamashita M, Kawaguchi SY, Hori T, Takahashi T.
    • Journal Title

      Cell Reports

      Volume: 22 Issue: 12 Pages: 3134-3141

    • DOI

      10.1016/j.celrep.2018.02.080

    • NAID

      120006425878

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Axonal GABAA receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells.2017

    • Author(s)
      Zorrilla de San Martin J, Trigo FF, Kawaguchi SY.
    • Journal Title

      The Journal of Physiology

      Volume: 595 Issue: 24 Pages: 7477-7493

    • DOI

      10.1113/jp275369

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fast Ca2+ Buffer-Dependent Reliable but Plastic Transmission at Small CNS Synapses Revealed by Direct Bouton Recording.2017

    • Author(s)
      Kawaguchi SY, Sakaba T.
    • Journal Title

      Cell Reports

      Volume: 21 Issue: 12 Pages: 3338-3345

    • DOI

      10.1016/j.celrep.2017.11.072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ca(2+) current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells.2015

    • Author(s)
      Francois Diaz-Rojas, Takeshi Sakaba, Shin-ya Kawaguchi
    • Journal Title

      The Journal of Physiology

      Volume: 593 Issue: 22 Pages: 4889-4904

    • DOI

      10.1113/jp270704

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Experimental and model analysis of transmitter release mechanisms at small presynaptic terminals in the CNS2017

    • Author(s)
      Shin-ya Kawaguchi
    • Organizer
      日本生理学大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Regulatory mechanism of transmitter release at a small presynaptic terminal.2017

    • Author(s)
      川口真也
    • Organizer
      日本神経科学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Biophysics and short-term plasticity in cerebellar small presynaptic terminals2016

    • Author(s)
      Shin-ya Kawaguchi
    • Organizer
      JSPS & OIST Joint Symposium
    • Place of Presentation
      OIST(沖縄県恩納村)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Short-term facilitation is predominantly mediated by presynaptic Ca2+ current facilitation at Purkinje cell - Purkinje cell synapses2015

    • Author(s)
      Francois Diaz-Rojas, Takeshi Sakaba, Shin-ya Kawaguchi
    • Organizer
      北米神経科学会大会 sfn2015
    • Place of Presentation
      米国 シカゴ
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 軸索終末での活動電位調節による短期シナプス可塑性2015

    • Author(s)
      川口真也、坂場武史
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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