| Project/Area Number |
15K06722
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyoto University (2017)
Doshisha University (2015-2016) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKABA Takeshi 同志社大学, 脳科学研究科, 教授 (80609511)
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| Research Collaborator |
DIAZ-ROJAS Francois 同志社大学, 脳科学研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 軸索終末 / シナプス / パッチクランプ / 小脳 / Ca緩衝 / GABA-A受容体 / 短期シナプス可塑性 / 伝達物質放出 / 軸索 / シナプス可塑性 / 伝達物質受容体 / 短期促通 / シナプス前部 / 受容体 / シナプス伝達 / 活動電位 / イメージング / 膜電位 |
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| Outline of Final Research Achievements |
Physiology of an axon and its terminals in the central nervous system remains elusive because of the difficulty to analyze the small size of structures. In this project, we clarified the dynamic regulation mechanism of information processing in the axon and terminals by using the direct patch-clamp recording technique together with local activation of transmitter by a spot laser illumination method. Specifically, we analyzed dynamic regulation mechanisms to control transmitter release from terminals of Purkinje cells and granule cells which mediate fine motor control.
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