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Understanding of taste information processing in the central nerve system and the decoding of taste information

Research Project

Project/Area Number 15K06731
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute of Information and Communications Technology

Principal Investigator

KIDA IKUHIRO  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳機能解析研究室, 主任研究員 (60374716)

Co-Investigator(Kenkyū-buntansha) 西本 伸志  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 主任研究員 (00713455)
上口 貴志  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳機能解析研究室, 主任研究員 (80403070)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsMRI / 超高磁場 / 脳機能 / 脳機能計測 / 味覚 / 磁気共鳴 / 撮像技術 / 脳活動 / fMRI / 食 / 島皮質
Outline of Final Research Achievements

To understand the mechanism of human gustatory function, it is necessary to use ultra-high magnetic field (UHF) strength (> 7 Tesla) MRI because the data should be highly accurate and signal to noise ratio. However, while UHF-MRI has the advantage of improving the sensitivity, subject motion and image distortion may impact to the accuracy and sensitivity with high spatial resolution. Therefore, we established the MR sequence with optimal parameters and the processing method for UHF fMRI. In addition, by controlling the taste stimulation, we successfully obtained reproducibly activation in gustatory functional regions with high spatial resolution as compared to 3 Tesla fMRI with respect to taste stimulation in the oral cavity. We try to extract taste information by coding the brain activations and predict how the subject feels the taste.

Academic Significance and Societal Importance of the Research Achievements

本研究では,従来の水準を越える高解像度で脳活動を再現性よく同定を可能としたことは、今後の味覚情報処理機構の解明に貢献できる。この機構の解明は、人々が豊かな生活を送るうえで重要な課題でもある。例えば、高齢化社会において重要視されている咀嚼や嚥下困難者向けの食品開発や,新規食品・調味料開発における消費者の反応予測などにおいて,ヒトが実際に感じている味覚の客観的評価を実現するものであり,産業や福祉の発展に大きく貢献すると考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (32 results)

All 2019 2018 2017 2016 2015

All Journal Article (9 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (23 results) (of which Int'l Joint Research: 10 results,  Invited: 4 results)

  • [Journal Article] Brain tissue segmentation based on MP2RAGE multi-contrast images in 7 T MRI.2019

    • Author(s)
      Choi US, Kawaguchi H, Matsuoka Y, Kober T, Kida I
    • Journal Title

      PLoS ONE

      Volume: 14 Issue: 2 Pages: 0210803-0210803

    • DOI

      10.1371/journal.pone.0210803

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optimized parameters for MP2RAGE images on 7-T MRI.2018

    • Author(s)
      Choi US, Kawaguchi H, Matsuoka Y, Kober T, Kida I
    • Journal Title

      Proceeding of International Society for Magnetic Resonance in Medicine

      Volume: - Pages: 4242-4242

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Olfactory functional magnetic resonance imaging in the human brain at 7 Tesla.2018

    • Author(s)
      Kida I, Donoshita Y, Choi US
    • Journal Title

      Proceeding of International Society for Magnetic Resonance in Medicine

      Volume: - Pages: 4552-4552

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Decoding naturalistic experiences from human brain activity via distributed representations of words.2018

    • Author(s)
      Nishida S, Nishimoto S
    • Journal Title

      NeuroImage

      Volume: - Pages: 232-242

    • DOI

      10.1016/j.neuroimage.2017.08.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脳情報を読み解く2018

    • Author(s)
      西本伸志
    • Journal Title

      情報処理

      Volume: 59 Pages: 48-53

    • Related Report
      2017 Research-status Report
  • [Journal Article] Comparison of diffusion-weighted imaging in human brain using readout-segmented EPI and PROPELLER turbo spin echo with single-shot EPI at 7 T MRI2016

    • Author(s)
      Kida I, Ueguchi T, Matsuoka Y, Zhou K, Stemmer A, Porter D
    • Journal Title

      Invest Radiol

      Volume: 未定 Issue: 7 Pages: 435-439

    • DOI

      10.1097/rli.0000000000000248

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Right ventrolateral prefrontal cortex involvement in the integration of emotional processing: Parametric mediation analysis of fMRI.2016

    • Author(s)
      Kida I, Hoshi Y
    • Journal Title

      Neuroscience Letters

      Volume: 615 Pages: 92-97

    • DOI

      10.1016/j.neulet.2016.01.009

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 匂いの脳機能イメージング:嗅覚機能へのfMRIの応用2015

    • Author(s)
      黄田育宏
    • Journal Title

      医学のあゆみ

      Volume: 253 Pages: 493-497

    • Related Report
      2015 Research-status Report
  • [Journal Article] Assessment of prospective motion correction using optical tracking system for reduction of stimulus-correlated false positive activations in high spatial resolution functional magnetic resonance imaging.2015

    • Author(s)
      Kida I, Ueguchi T, Matsuoka Y, Zaitsev M
    • Journal Title

      Proceedings of the International Society for Magnetic Resonance in Medicine

      Pages: 2058-2058

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] A fast segmentation method of brain tissue using MP2RAGE at 7 T MRI.2018

    • Author(s)
      Choi US, Matsuoka Y, Kawaguchi H, Kida I
    • Organizer
      26th Scientific Meeting & Exhibition, International Society for Magn Reson Med
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Olfactory functional magnetic resonance imaging in the human brain at 7 Tesla.2018

    • Author(s)
      Kida I, Donoshita Y, Choi US
    • Organizer
      26th Scientific Meeting & Exhibition, International Society for Magn Reson Med
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stability of odor activation in the human brain using 7 Tesla fMRI.2018

    • Author(s)
      Kida I, Donoshita Y, Choi US
    • Organizer
      OHBM2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional MRI study of the human amygdala using multi-echo multi-band EPI at 7 Tesla.2018

    • Author(s)
      Choi US, Tanaka T, Haruno M, Kida I
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 7Tにおけるヒト脳1H-MRSについての検討2018

    • Author(s)
      圓見 純一郎,李 欣洋,黄田 育宏,吉岡 芳親
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Gut umami sensing modulates functional connectivity in the human brain: Preliminary results using resting-state fMRI.2017

    • Author(s)
      Kida I, Nawa NE, Matsuoka Y, Leibnitz K
    • Organizer
      1st International Soc Magn Reson Med Japanese Chapter
    • Place of Presentation
      脳情報通信融合研究センター,吹田市,大阪府
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Changes in apparent diffusion coefficient during visual stimulation.2017

    • Author(s)
      Kida I, Ban H, Matsuoka Y
    • Organizer
      1st International Soc Magn Reson Med Japanese Chapter
    • Place of Presentation
      脳情報通信融合研究センター,吹田市,大阪府
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Umami ingestion modulates functional connectivity in the human brain: A resting-state fMRI study.2017

    • Author(s)
      Kida I, Nawa NE, Matsuoka Y, Leibnitz K
    • Organizer
      OHBM2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] fMRIの基礎と化学感覚への応用2017

    • Author(s)
      黄田育宏
    • Organizer
      第18回NMR若手研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Calibrated fMRIにおける脳循環代謝カップリング2017

    • Author(s)
      黄田育宏
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Quantitative four-dimensional motility tracking of individual immune cells in living mouse brain.2017

    • Author(s)
      Mori Y, Martinez de la Mora D, Tashita A, Kobashi S, Kida I, Hata Y, Yoshioka Y
    • Organizer
      25th Scientific Meeting & Exhibition, International Society for Magn Reson Med
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pulvinar modulates primary visual cortex in a laminar dependent manner during perception of fear.2017

    • Author(s)
      Koizumi A, Zhan M, Ban H, Kida I, Vaessen M, de Gelder B, Amano K
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Parameter optimization of the MP2RAGE sequence at 7 Tesla MRI.2017

    • Author(s)
      Choi U, 川口浩和, 松岡雄一郎, 黄田育宏
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 7T-MRI送受信コイルの共振特性に対するシールドの影響.2017

    • Author(s)
      松岡雄一郎, 黄田育宏
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Four-dimensional in vivo MRI for tracking individual immune cells in mouse brain2016

    • Author(s)
      Mori Y, de la Mora DM, Tashita A, Kobashi S, Kida I, Hata Y, Yoshioka Y
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ,さいたま市,埼玉県
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Quantitative comparison between conventional and accelerated NODDI maps of the brain2016

    • Author(s)
      Ueguchi T, Kida I, Kobayashi Y, Okada K, Kadono Y, Yamada S, Liu G
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ,さいたま市,埼玉県
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 超高磁場ヒト脳MRI:マルチスライス撮像に由来する空間的に不均一な磁化移動効果2016

    • Author(s)
      上口貴志,黄田育宏,劉国相
    • Organizer
      第111回日本医学物理学会
    • Place of Presentation
      パシフィコ横浜会議センター,横浜市,神奈川県
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Functional magnetic resonance imaging of the olfactory and gustatory system2015

    • Author(s)
      Kida I
    • Organizer
      9th International Symposium on Nanomedicine
    • Place of Presentation
      三重大学,津,三重県
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Detection of white matter activation using diffusion weighted imaging by a 7Tesla human MRI system.2015

    • Author(s)
      Kida I, Ueguchi T, Matsuoka Y, Zhou K, Stemmer A
    • Organizer
      45th Annual Meeting of Society of Neuroscience
    • Place of Presentation
      McCormick Place,シカゴ,アメリカ
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] fMRIによる化学感覚の情報処理機構.2015

    • Author(s)
      黄田育宏
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル,文京区,東京都
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] マルチスライス撮像に伴うMT効果:7T脳画像での評価.2015

    • Author(s)
      上口貴志,黄田育宏,松岡雄一郎,劉 国相
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル,文京区,東京都
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Assessment of prospective motion correction using optical tracking system for reduction of stimulus-correlated false positive activations in high spatial resolution functional magnetic resonance imaging.2015

    • Author(s)
      Kida I, Ueguchi T, Matsuoka Y, Zaitsev M
    • Organizer
      23rd Scientific Meeting & Exhibition, International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Metro Toronto Convention Centre,トロント,カナダ
    • Year and Date
      2015-05-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Improved T1 correction for cardiac-triggered fMRI at ultra-high field.2015

    • Author(s)
      Ueguchi T, Kida I, Liu G
    • Organizer
      第109回日本医学物理学会学術大会
    • Place of Presentation
      パシフィコ横浜会議センター,横浜,神奈川県
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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