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The roles of the chamorepellent draxin in hippocampal neurogenesis

Research Project

Project/Area Number 15K06733
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTohoku University

Principal Investigator

Tawarayama Hiroshi  東北大学, 医学系研究科, 助教 (20402414)

Project Period (FY) 2015-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsdraxin / DCC / 海馬神経新生 / アポトーシス / 神経分化 / hippocampal neurogenesis / neuronal cell death
Outline of Final Research Achievements

Hippocampal neurogenesis in the dentate gyrus (DG) is controlled by various diffusible molecules that modulate neurogenic processes. To elucidate the mechanisms underlying hippocampal neurogenesis, we investigated the function of draxin in the regulation of neuronal survival in the DG. Draxin was expressed in Tbr2 (+) late progenitors and NeuroD1 (+) neuroblasts in the dentate granule cell lineage, whereas expression of its receptor DCC was mainly detectable in neuroblasts. Our phenotypic analysis revealed that draxin deficiency led to enhanced apoptosis of DCC-expressing neuroblasts in the neurogenic areas. Furthermore, in vitro assays using a hippocampal neural stem/progenitor cell (HNSPC) line indicated that draxin inhibited apoptosis in differentiating HNSPCs, which express DCC. Taken together, we postulate that draxin plays a pivotal role in postnatal DG neurogenesis as a dependence receptor ligand for DCC to maintain and promote survival of neuroblasts.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Int'l Joint Research] The University of Queensland(Australia)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] The University of Queensland(オーストラリア)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis.2018

    • Author(s)
      Tawarayama H, Yamada H, Amin R, Morita-Fujimura Y, Cooper HM, Shinmyo Y, Kawata M, Ikawa S, Tanaka H.
    • Journal Title

      Sci Rep.

      Volume: 8(1) Issue: 1 Pages: 840-840

    • DOI

      10.1038/s41598-018-19346-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation2017

    • Author(s)
      Maekawa Shigeto、Sato Kota、Fujita Kosuke、Daigaku Reiko、Tawarayama Hiroshi、Murayama Namie、Moritoh Satoru、Yabana Takeshi、Shiga Yukihiro、Omodaka Kazuko、Maruyama Kazuichi、Nishiguchi Koji M.、Nakazawa Toru
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41598-017-06969-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors.2017

    • Author(s)
      Kunikata H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 41984-41984

    • DOI

      10.1038/srep41984

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ΔNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines.2016

    • Author(s)
      Amin R, Morita-Fujimura Y, Tawarayama H, Semba K, Chiba N, Fukumoto M, Ikawa S
    • Journal Title

      Molecular Oncology

      Volume: 10 Issue: 4 Pages: 575-593

    • DOI

      10.1016/j.molonc.2015.11.009

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis and Wnt-driven differentiation2016

    • Author(s)
      俵山寛司、山田博久、藤村維子、Ruhul Amin、Helen M Cooper、新明洋平、河田雅圭、井川俊太郎、田中英明
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report

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Published: 2015-10-21   Modified: 2019-03-29  

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