Structural Analysis of glial cells by using high resolution imaging method
| Project/Area Number |
15K06734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Iwasaki Hirohide 東京大学, 大学院医学系研究科(医学部), 講師 (30342752)
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| Co-Investigator(Renkei-kenkyūsha) |
OKABE Shigeo 東京大学, 大学院医学系研究科, 教授 (60204012)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | グリア細胞 / 微細形態解析 / 電子顕微鏡 / 光学顕微鏡 / ミクログリア / FIB-SEM / 神経科学 / 解剖学 |
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| Outline of Final Research Achievements |
In the central nervous system of the mammalian brain, three types of glial cells have been identified; astrocyte, microglia and oligodendrocyte. Among them, oligodendrocyte forms myelin around axons. Other types of glial cells might contribute to the synaptic functions of the brain by affecting the synapse formation/elimination.
In this research, I analyzed the precise structure of astrocyte and microglia by using CLEM (Correlative anaylysis of light- and electron- microscopy) method. Particularly, I succeeded the comprehensive three-dimensional reconstruct of the fine protrusions of single microglia.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.2018
Author(s)
Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ.
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Journal Title
Science
Volume: 359
Issue: 6376
Pages: 679-684
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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