Molecular mechanism of Reelin-induced neuronal aggregation in the developing mouse cereberal cortex
| Project/Area Number |
15K06745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
Inoue Seika
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 発生 / 大脳新皮質 / 層構造 / 細胞凝集 / 細胞接着 / Reelin / N-cadherin / 神経細胞凝集 |
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| Outline of Final Research Achievements |
The mammalian neocortex has the six layered structure organized by excitatory neurons, which enables higher brain functions. A secretary molecule ‘Reelin’ is essential for the layer formation, but the molecular mechanism based on Reelin for the layer formation remains to be elucidated. The purpose of the current project is to clarify cellular and molecular mechanisms to form the layered structure based on Reelin during cortical development.
In this study, we found that Reelin-inducible neuronal aggregate was mediated by N-cadherin-based cellular adhesion and that this promotion of cellular adhesion by Reelin was in a transient manner. Moreover, we revealed p120 catenin and Nck were involved in this N-cadherin-based cellular adhesion. These results were presented in several scientific meetings and published in an international journal.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination2017
Author(s)
Hayashi K, Furuya A, Sakamaki Y, Akagi T, Shinoda Y, Sadakata T, Hashikawa T, Shimizu K, Minami H, Sano Y, Nakayama M, and Furuichi T.
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Journal Title
PLoS ONE
Volume: 12
Issue: 3
Pages: e0173175-e0173175
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain2015
Author(s)
Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume: 112(36)
Issue: 36
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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