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Analysis of the neuronal migration regulation mechanism by post-translational modification of Dab1

Research Project

Project/Area Number 15K06746
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKeio University

Principal Investigator

Honda Takao  慶應義塾大学, 医学部(信濃町), 講師 (30365225)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsDab1 / Reelin / 翻訳後修飾 / reeler / yotari / dab1 / リン酸化 / 神経細胞移動 / 大脳新皮質
Outline of Final Research Achievements

Dab1 is an intracellular protein that has an essential role in neuronal migration of cerebral cortical neurons and formation of their dendrites. So far, it has been shown that posttranslational modification of tyrosine residues of Dab1 has essential roles in Reelin signaling pathway, however it remains unknown whether other amino acid residues which might be post-translationally modified are involved in Reelin-Dab1 signaling pathway. We found that some amino acids sequences are highly conserved among different species in the primary sequence of Dab1, and thus hypothesized that those sequences might be post-translationally modified. Thus, we examined the possibility of functional control of Dab1 by those amino acids. As a result, we found that the putative posttranslational modification sites are required for the correct neuronal migration.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Proper level of cytosolic Disabled-1, which is regulated by dual nuclear translocation pathways, is important for cortical neuronal migration.2015

    • Author(s)
      Honda T and Nakajima K
    • Journal Title

      Cereb. Cortex

      Volume: bhv162 Issue: 7 Pages: 1-18

    • DOI

      10.1093/cercor/bhv162

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain2015

    • Author(s)
      Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlen and Kazunori Nakajima
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 112(36) Issue: 36

    • DOI

      10.1073/pnas.1420701112

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Dab1 haploinsufficiency causes invasion of superficial cortical neurons into layer I and splitting of CA1 pyramidal cell layer2018

    • Author(s)
      本田岳夫、仲嶋一範
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] dab1のハプロ不全は表層神経細胞の大脳皮質第一層への侵入とCA1錐体細胞層の分離を引き起こす(Haploinsufficiency of dab1 causes invasion of superficial-layer neurons into the cortical layer I and splitting of the CA1 pyramidal cell layer)2017

    • Author(s)
      本田岳夫、仲嶋一範
    • Organizer
      2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会・第90回日本生化学会大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dab1 haploinsufficiency causes reduction of layer I thickness and splitting of CA1 pyramidal cell layer2017

    • Author(s)
      本田岳夫、仲嶋一範
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dab1 haploinsufficiency causes superficial shift of later-born cortical neuron positioning and splitting of the CA1 pyramidal cell layer (Dab1のハプロ不全は大脳新皮質遅生まれニューロンの脳表層側配置と海馬CA1錐体細胞層の分離を引き起こす)2017

    • Author(s)
      本田岳夫、仲嶋一範
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reelin coupled with myelin may play a role in long term maintenance of myelin (リーリンは、ミエリンの長期維持の役割を果たしている)2016

    • Author(s)
      Kimiko Deguchi,Takao Honda, Ken-ichiro Kubo, Kazunori Nakajima,and Ken Inoue
    • Organizer
      第58回日本小児神経学会学術集会
    • Place of Presentation
      京王プラザホテル新宿、新宿(東京都)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Reelin coupled with myelin may play a role in long-term maintenance of myelin2016

    • Author(s)
      Kimiko Deguchi, Takao Honda, Ken-ichiro Kubo, Kazunori Nakajima, and Ken Inoue
    • Organizer
      21st Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2016)
    • Place of Presentation
      Palais des Congres d’Antibes Juan les Pins, Antibes-Juan les Pins, France
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Presentation] Analysis of the role of Dab1 nucleo-cytoplasmic transport for migration of excitatory neurons (Dab1の核細胞質間輸送が興奮性神経細胞の移動に果たす役割の解明)2016

    • Author(s)
      Takao Honda and Kazunori Nakajima
    • Organizer
      第9回神経発生討論会・難治疾患共同研究拠点共同開催学術集会
    • Place of Presentation
      東京医科歯科大学M&Dタワー鈴木章夫記念講堂(東京都、文京区)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] C-terminal region of Reelin is required for development and maintenance of the postnatal cerebral cortex and its functions are regulated by specific proteolysis2016

    • Author(s)
      Takao Kohno, Takao Honda, Ken-ichiro Kubo, Yoshimi Nakano, Ayaka Tsuchiya, Tatsuro Murakami, Hideyuki Banno, Kazunori Nakajima, and Mitsuharu Hattori
    • Organizer
      新学術領域研究「神経細胞の多様性と大脳新皮質の構築」第3回国際シンポジウム「Neocortical Organization 3」
    • Place of Presentation
      東京大学小柴ホール(東京都、文京区)
    • Year and Date
      2016-02-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Dab1核細胞質間シャトリングの大脳新皮質層形成における役割の解明2015

    • Author(s)
      本田岳夫、仲嶋一範
    • Organizer
      日本解剖学会関東支部 第103回学術集会
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県、横浜市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 二つの核移行経路による細胞質Dab1量の適切な調節が興奮性神経細胞移動に重要である2015

    • Author(s)
      本田岳夫、仲嶋一範
    • Organizer
      第50回慶應ニューロサイエンス研究会
    • Place of Presentation
      慶應義塾大学信濃町キャンパス(東京都、新宿区)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis2015

    • Author(s)
      Takao Kohno, Takao Honda, Ken-ichiro Kubo, Yoshimi Nakano, Ayaka Tsuchiya, Tatsuro Murakami, Hideyuki Banno, Kazunori Nakajima, and Mitsuharu Hattori.
    • Organizer
      Society for Neuroscience, Neuroscience 2015 meeting
    • Place of Presentation
      McCormick Place, Chicago, U.S.A
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 二つの核移行経路による細胞質Dab1量の適切な調節が大脳皮質ニューロンの移動に重要である(Proper level of cytosolic Disabled-1, which is regulated by dual nuclear translocation pathways, is important for cortical neuronal migration)2015

    • Author(s)
      本田岳夫、仲嶋一範
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・神戸国際展示場(兵庫県、神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 巨大分泌蛋白質リーリンのC末端領域を介した大脳皮質形成機構2015

    • Author(s)
      河野孝夫、本田岳夫、久保健一郎、中野良美、土屋綾香、村上達郎、阪野英幸、仲嶋一範、服部光治
    • Organizer
      第61回日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋市立大学(愛知県、名古屋市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report
  • [Presentation] Evidence of a link between TDP-43 and dipeptide repeat protein in c9FTD/ALS2015

    • Author(s)
      Mai Yamakawa, Daisuke Ito, Takao Honda, Ken-ichiro Kubo, Mariko Noda, and Kazunori Nakajima, and Norihiro Suzuki
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県、新潟市)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2023-12-25  

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