| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The aim of the present study is to assess whether oligodendroglial iron overload and augmentation of oxidative stress play a role in the pathogenesis of multiple system atrophy (MSA). We performed histological and immunohistological analysis using autopsied specimens obtained form 11 cases of MSA with varying disease severity and 4 control subjects. In the putamen of the patients with MSA, iron- and ferritin-positive oligodendroglias were observed. The number of these iron-positive oligodendroglias appeared to be inversely correlated with the intensity of myelin staining of the striatal-pallidal fibers. The affected oligodendroglias in the striatum were also positive for some of the oxidative stress markers, including the malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE). These results suggest that in MSA, iron overload and resultant augmentation of oxidative stress in the oligodendroglias may be associated with the altered myelination of the striatal-pallidal fibers.
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