Multiple system atrophy: the pathogenic role of oligodendroglial iron overload and oxidative stress
| Project/Area Number |
15K06752
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
豊島 靖子 新潟大学, 脳研究所, 准教授 (20334675)
高橋 均 新潟大学, 脳研究所, 教授 (90206839)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 多系統萎縮症 / 鉄 / 酸化ストレス / 乏突起膠細胞 / 鉄代謝 |
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| Outline of Final Research Achievements |
The aim of the present study is to assess whether oligodendroglial iron overload and augmentation of oxidative stress play a role in the pathogenesis of multiple system atrophy (MSA). We performed histological and immunohistological analysis using autopsied specimens obtained form 11 cases of MSA with varying disease severity and 4 control subjects. In the putamen of the patients with MSA, iron- and ferritin-positive oligodendroglias were observed. The number of these iron-positive oligodendroglias appeared to be inversely correlated with the intensity of myelin staining of the striatal-pallidal fibers. The affected oligodendroglias in the striatum were also positive for some of the oxidative stress markers, including the malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE). These results suggest that in MSA, iron overload and resultant augmentation of oxidative stress in the oligodendroglias may be associated with the altered myelination of the striatal-pallidal fibers.
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Report
(4 results)
Research Products
(1 results)
