The role of dopaminergic signaling from the ventral tegmental area to the medial prefrontal cortex in the expression of cocaine-associated addictive behaviors
| Project/Area Number |
15K06765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | addiction / ventral tegmental area / medial prefrontal cortex / cocaine / dopamine / craving / 薬物依存 / 腹側被蓋野 / 内側前頭前野 / ドパミン / コカイン / 渇望 / 報酬記憶 / 脳内報酬系 |
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| Outline of Final Research Achievements |
Reinstatement of drug use is a critical problem of drug addiction. In this study, using the conditioned place preference paradigm combined with electrophysiological recordings, optogenetics and chemogenetic techniques, we found that dopaminergic transmission in the medial prefrontal cortex (mPFC), one of the target brain regions of dopamine neurons in the ventral tegmental area, plays a critical role for inducing the reinstatement of cocaine use. Our data show that excitation of mPFC neurons, which is mediated by D1 dopamine receptor signaling, induces cocaine craving behaviors, including reinstatement.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Activation of GABAergic neurons in the nucleus accumbens mediates the expression of cocaine-associated memory.2018
Author(s)
Zhang, T., Deyama, S., Domoto, M., Wada, S., Yanagida, J., Sasase, H., Hinoi, E., Nishitani, N., Nagayasu, K., Kaneko, S., Kaneda, K.
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Journal Title
Biological Pharmaceutical Bulletin
Volume: 印刷中
NAID
Related Report
Peer Reviewed
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