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The role of dopaminergic signaling from the ventral tegmental area to the medial prefrontal cortex in the expression of cocaine-associated addictive behaviors

Research Project

Project/Area Number 15K06765
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKanazawa University

Principal Investigator

Kaneda Katsuyuki  金沢大学, 薬学系, 教授 (30421366)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsaddiction / ventral tegmental area / medial prefrontal cortex / cocaine / dopamine / craving / 薬物依存 / 腹側被蓋野 / 内側前頭前野 / ドパミン / コカイン / 渇望 / 報酬記憶 / 脳内報酬系
Outline of Final Research Achievements

Reinstatement of drug use is a critical problem of drug addiction. In this study, using the conditioned place preference paradigm combined with electrophysiological recordings, optogenetics and chemogenetic techniques, we found that dopaminergic transmission in the medial prefrontal cortex (mPFC), one of the target brain regions of dopamine neurons in the ventral tegmental area, plays a critical role for inducing the reinstatement of cocaine use. Our data show that excitation of mPFC neurons, which is mediated by D1 dopamine receptor signaling, induces cocaine craving behaviors, including reinstatement.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Activation of GABAergic neurons in the nucleus accumbens mediates the expression of cocaine-associated memory.2018

    • Author(s)
      Zhang, T., Deyama, S., Domoto, M., Wada, S., Yanagida, J., Sasase, H., Hinoi, E., Nishitani, N., Nagayasu, K., Kaneko, S., Kaneda, K.
    • Journal Title

      Biological Pharmaceutical Bulletin

      Volume: 印刷中

    • NAID

      130007387205

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry.2018

    • Author(s)
      Shinohara, F., Asaoka, Y., Kamii, H., Minami, M., Kaneda, K.
    • Journal Title

      Addiction Biology

      Volume: 印刷中 Issue: 3 Pages: 509-521

    • DOI

      10.1111/adb.12617

    • NAID

      120006627077

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effects of morphine injected into the ventral bed nucleus of the stria terminalis on the affective, but not sensory, component of pain in rats2017

    • Author(s)
      Maruyama Chikashi、Deyama Satoshi、Nagano Yusuke、Ide Soichiro、Kaneda Katsuyuki、Yoshioka Mitsuhiro、Minami Masabumi
    • Journal Title

      Eur J Neurosci.

      Volume: 47 Issue: 1 Pages: 40-47

    • DOI

      10.1111/ejn.13776

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M. Minami, Resolvin E1 and E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR232017

    • Author(s)
      K. Deyama, Y. Shimoda, K. Ishikawa, H. Ishimura, H. Fukuda, S. Ide, M. Satoh, S. Shuto
    • Journal Title

      Psychopharmacology

      Volume: 235 Issue: 1 Pages: 329-336

    • DOI

      10.1007/s00213-017-4774-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Dopaminergic Signaling in the Medial Prefrontal Cortex for the Expression of Cocaine-Induced Conditioned Place Preference in Rats2017

    • Author(s)
      Shinohara, F., Kamii, H., Minami, M., Kaneda, K.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 11 Pages: 1983-1989

    • DOI

      10.1248/bpb.b17-00614

    • NAID

      130006191992

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide in the medial prefrontal cortex contributes to the acquisition of cocaine place preference and synaptic plasticity in the laterodorsal tegmental nucleus.2017

    • Author(s)
      Kamii, H., Taoka, N., Minami, M., Kaneda, K.
    • Journal Title

      Neuroscience Letters

      Volume: 660 Pages: 39-44

    • DOI

      10.1016/j.neulet.2017.09.015

    • NAID

      120006374154

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of neuroplasticity in cholinergic neurons of the laterodorsal tegmental nucleus for cocaine addiction.2016

    • Author(s)
      Kaneda K, Kamii H, Taoka N, Minami M.
    • Journal Title

      Nihon Arukoru Yakubutsu Igakkai Zasshi

      Volume: 51(5) Pages: 259-267

    • NAID

      40021022181

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factor within the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion.2016

    • Author(s)
      Kaneko T, Kaneda K, Ohno A, Takahashi D, Hara T, Amano T, Ide S, Yoshioka M, Minami M
    • Journal Title

      Eur. J. Neurosci.

      Volume: 44 Issue: 11 Pages: 2914-2924

    • DOI

      10.1111/ejn.13419

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Chronic cocaine exposure induces noradrenergic modulation of inhibitory synaptic transmission to cholinergic neurons of the laterodorsal tegmental nucleus.2016

    • Author(s)
      Taoka N, Kamiizawa R, Wada S, Minami M, Kaneda K.
    • Journal Title

      European Journal of Neuroscience

      Volume: 44(12) Issue: 12 Pages: 3035-3045

    • DOI

      10.1111/ejn.13405

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 側座核GABAニューロンの活動がcocaine探索行動の発現に及ぼす影響2018

    • Author(s)
      Zhang Tong, 堂本 将輝, 柳田 淳子, 出山 諭司, 檜井栄一, 金田 勝幸
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role of noradrenergic transmission in the medial prefrontal cortex for acute restraint stress-induced augmentation of cocaine reward2017

    • Author(s)
      金田勝幸, 和田進太郎, 柳田淳子, 上居寛典, 堂本将輝, 出山諭司
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 薬物探索行動発現における脳幹-中脳-皮質神経回路の役割2017

    • Author(s)
      金田勝幸
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレス負荷によるコカイン欲求行動における内側前頭前野ノルアドレナリン神経伝達の関与2017

    • Author(s)
      和田 進太郎, 柳田 淳子, 堂本 将輝, 笹瀨 人暉, 張 タン;, 松下 夏子, 出山 諭司, 檜井 栄一, 金田 勝幸
    • Organizer
      日本薬学会北陸支部第129回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コカイン依存形成における背外側被蓋核コリン作動性ニューロンの可塑性と内側前頭前野のNOの役割2016

    • Author(s)
      金田 勝幸, 上居 寛典, 田岡 直史, 和田 進太郎, 南 雅文
    • Organizer
      平成28年度日本アルコール・アディクション医学会学術総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Involvement of brainstem noradrenaline system in acute stress-induced enhancement of cocaine craving behavior2016

    • Author(s)
      金田 勝幸
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 会議センター(横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Identification of neuronal ensembles in the entire striatum that coincides with the transition period from goal-directed to habitual during instrumental learnig2016

    • Author(s)
      Lin Z, Nishikawa H, Kaneda K, Iguchi Y, Minabe Y, Hope B.T., Toda S
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 会議センター(横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Carbachol attenuates excitatory synaptic transmission in cholinergic neurons of the laterodorsal tegmental nucleus.2016

    • Author(s)
      Kamiizawa K, Minami M, Kaneda K
    • Organizer
      30th CINP WORLD CONGRESS OF NEUROPSYCHOPHARMACOLOGY
    • Place of Presentation
      ソウル (韓国)
    • Year and Date
      2016-07-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 背外側被蓋核コリン作動性ニューロンに対するカルバコールの作用2016

    • Author(s)
      上伊澤 涼太, 南 雅文, 金田 勝幸
    • Organizer
      第46回 日本神経精神薬理学会年会
    • Place of Presentation
      ソウル (韓国)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 内側前頭前野ニューロンに対するノルアドレナリンの興奮作用メカニズム2016

    • Author(s)
      和田 進太郎, 堂本 将輝, 金田 勝幸
    • Organizer
      第130回日本薬理学会近畿部会
    • Place of Presentation
      京都大学百周年時計台記念館(京都)
    • Related Report
      2016 Research-status Report
  • [Presentation] 内側前頭前野における危険ドラッグ5F-AMBの作用2016

    • Author(s)
      堂本 将輝, 和田進太郎, 出山 諭司, 金子 周司, 金田 勝幸
    • Organizer
      第130回日本薬理学会近畿部会
    • Place of Presentation
      京都大学百周年時計台記念館(京都)
    • Related Report
      2016 Research-status Report
  • [Presentation] 急性ストレス負荷によるコカイン誘導性場所嗜好性増強における内側前頭前野の役割2016

    • Author(s)
      柳田淳子, 上居寛典, 和田進太郎, 宝田剛志, 出山諭司, 金田勝幸
    • Organizer
      日本薬学会北陸支部第128回例会
    • Place of Presentation
      北陸大学アネックスファーム(金沢)
    • Related Report
      2016 Research-status Report
  • [Presentation] Neural mechanisms of acute stress-induced enhancement of cocaine craving behavior.2015

    • Author(s)
      Katsuyuki Kaneda
    • Organizer
      International Symposium on Prediction and Decision Making 2015
    • Place of Presentation
      The University of Tokyo (Tokyo)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳幹コリン作動性ニューロンを含む神経回路のコカイン依存形成における役割2015

    • Author(s)
      金田 勝幸
    • Organizer
      平成27年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Research-status Report
  • [Remarks] 金沢大学医薬保健研究域薬学系 薬理学研究室ホームページ

    • URL

      http://www.p.kanazawa-u.ac.jp/~yakuri/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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