A new approach for the development of dementia prevention aiming at preemptive medicine based on the regulation of amyloid-beta levels by unused functions of biophenols and existing drugs
Project/Area Number |
15K06766
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Hirosaki University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
丹治 邦和 弘前大学, 医学研究科, 助教 (10271800)
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Project Period (FY) |
2015-10-21 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | アルツハイマー病 / アミロイドβ / レバミピド / グネチンC / レスベラトロール二量体 / ε-ビニフェリン / レスベラトロール / 認知症予防 / 神経変性疾患予防 / カルノシン酸 / エダラボン / 脳保護 |
Outline of Final Research Achievements |
The present study revealed that rebamipide, a gastrointestinal protective drug, partially ameliorated the reduced cell viability observed after the treatment of Aβ 1-43 (Aβ43; a higher neurotoxic Aβ peptide) in a cultured model of human neurons (SH-SY5Y human neuroblastoma cells). In addition, rebamipide reduced endogenous Aβ 1-42 (Aβ42) secretion. Next, we found that gnetin C, a trans-resveratrol dimer isolated from melinjo, efficiently reduced Aβ42 production. The effect of gnetin C was higher than that of ε-viniferin (a trans-resveratrol dimer isolated from grape vine) or resveratrol monomer. Furthermore, gnetin C significantly ameliorated the exogenous Aβ42-lowered cell viability. These results may lead to the development of means for preventing Aβ-mediated diseases, particularly Alzheimer’s disease.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Gnetin C, a resveratrol dimer, reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ42-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.2018
Author(s)
Seino S, Kimoto T, Yoshida H, Tanji K, Matsumiya T, Hayakari R, Seya K, Kawaguchi S, Tsuruga K, Tanaka H, Imaizumi T.
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Journal Title
Biomed Res (Tokyo)
Volume: 39
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Toll-like receptor 3 signaling contributes to regional neutrophil recruitment in cultured human glomerular endothelial cells.2018
Author(s)
Qiang L, Imaizumi T, Kawaguchi S, Aizawa T, Matsumiya T, Watanabe S, Tsugawa K, Yoshida H, Tsuruga K, Joh K, Kijima H, Tanaka H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] <b>CCL5 is induced by TLR 3 signaling in HuCCT1 human biliary epithelial cells: possible involvement in the pathogenesis of biliary atr</b><b>esia </b>2017
Author(s)
Shimada T, Imaizumi T, Shirai K, Tatsuta T, Hayakari R, Yoshida H, Matsumiya T, Kimura T, Kijima K, Mizukami H, Hakamada K.
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Journal Title
Biomedical Research
Volume: 38
Issue: 5
Pages: 269-276
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cylindromatosis (CYLD), a deubiquitinase, attenuates inflammatory signaling pathways by activating Toll-like receptor 3 in human mesangial cells.2017
Author(s)
Imaizumi T, Hayakari R, Watanabe S, Aizawa T, Matsumiya T, Yoshida H, Tsuruga K, Kawaguch S, Tanaka H
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Journal Title
Kidney and Blood Pressure Research
Volume: 42
Issue: 5
Pages: 942-950
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.2016
Author(s)
Imaizumi T, Yano C, Numata A, Tsugawa K, Hayakari R, Matsumiya T, Yoshida H, Watanabe S, Tsuruga K, Kawaguchi S, Murakami M, Tanaka H.
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Journal Title
Kidney Blood Press Res
Volume: 41
Pages: 635-642
NAID
Related Report
Peer Reviewed
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[Journal Article] Interferon-Dependent Transcript, Is Involved in a Negative Feedback Loop in Innate Immune Reactions in Human Mesangial Cells.2016
Author(s)
Imaizumi T, Shimada T, Matsumiya T, Yoshida H, Watanabe S, Tsuruga K, Kawaguchi S, Murakami M, Joh K, Tanaka H.
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Journal Title
Nephron
Volume: 132
Issue: 2
Pages: 144-152
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.2015
Author(s)
Chiba Y, Matsumiya T, Satoh T, Hayakari R, Furudate K, Xing F, Yoshida H, Tanji K, Mizukami H, Imaizumi T, Ito E.
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Journal Title
Biochem Biophys Res Commun
Volume: 467
Issue: 2
Pages: 191-196
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Interferon-stimulated gene (ISG) 60, as well as ISG56 and ISG54, positively regulates TLR3/IFN-β/STAT1 axis in U373MG human astrocytoma cells.2015
Author(s)
Imaizumi T, Yoshida H, Hayakari R, Xing F, Wang L, Matsumiya T, Tanji K, Kawaguchi S, Murakami M, Tanaka H.
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Journal Title
Neurosci Res
Volume: Epub ahead of print
Pages: 000-000
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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