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Development of biomarker based on the pathogenesis of Parkinson's disease

Research Project

Project/Area Number 15K06780
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionJuntendo University

Principal Investigator

SATO SHIGETO  順天堂大学, 医学部, 准教授 (00445537)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsパーキンソン病 / Parkin / ミトコンドリア / 神経変性疾患 / バイオマーカー / 認知症 / リン酸化 / PINK1 / マウス / CCCP / Parkin / Atp13a2 / リソソーム
Outline of Final Research Achievements

Abnormal mitochondrial accumulation leads to cell dysfunction and causes various pathological conditions such as cancer and degenerative diseases. At that time, it is speculated that the defective mitochondrial removal mechanism is triggered. Phosphorylation signals for activation of removal mechanisms, which have been clarified in in vitro systems, can be indicators of neurodegeneration. As a result of searching the brain pathology sample, it was suggested that the phosphorylation of Parkin is enhanced in the neuronal cells causing neurofibrillary tangles.

Academic Significance and Societal Importance of the Research Achievements

In vitroで明らかになりつつある不良ミトコンドリア除去機構が実際に生体内で機能しているかは不明であり今後のさらなる研究が必要である。認知症病理標本でリン酸化シグナルが亢進しているとの本研究結果は認知症の病態解明に迫るものであると同時に新たなバイオマーカーを提案するものである。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Dopaminergic Neuron-Specific Autophgy-Deficient Mice.2018

    • Author(s)
      Sato S, Hattori N
    • Journal Title

      Methods Mol Biol.

      Volume: 1759 Pages: 173-175

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.2018

    • Author(s)
      Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 2813-2813

    • DOI

      10.1038/s41598-018-21325-w

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysosomal storage of subunit c of mitochondrial ATP synthase in brain-specific Atp13a2-deficient mice.2016

    • Author(s)
      Sato S
    • Journal Title

      Am. J. Pathol

      Volume: 186 Pages: 3074-3082

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells2016

    • Author(s)
      Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H.
    • Journal Title

      Stem Cell Reports.

      Volume: 6 Issue: 3 Pages: 422-35

    • DOI

      10.1016/j.stemcr.2016.01.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Pathological perspective on autophagy lysosomal pathway in Parkinson’s disease2015

    • Author(s)
      佐藤栄人
    • Organizer
      GEO-PD
    • Place of Presentation
      六本木アカデミーヒルズ
    • Year and Date
      2015-10-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2020-03-30  

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