A study on neuroprotection by glia-derived lipoproteins against nerve injury
| Project/Area Number |
15K06781
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Tokyo University of Pharmacy and Life Science |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
Vance Jean E. アルバータ大学, 医学部, 教授
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 緑内障 / リポタンパク質 / グルタミン酸 / アルファ２マクログロブリン / 神経変性 / 神経保護 |
|---|
| Outline of Final Research Achievements |
Glaucoma is one of the neurodegenerative disorders and the leading cause of blindness in Japan. In our previous study, apolipoprotein E-containing lipoproteins strongly protect primary cultured retinal ganglion cells from glutamate-induced neurodegeneration. Here, we determined a novel neuroprotective mechanism of apolipoprotein E-containing lipoproteins and defined roles of an inhibitory factor against the protective effect of apolipoprotein E-containing lipoproteins.
|
Report
(4 results)
Research Products
(26 results)
