Manipulation of the activity of parvalbumin-expressing interneurons against post-traumatic stress disorder
| Project/Area Number |
15K06784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hoshi University |
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Principal Investigator |
Tamura Hideki 星薬科大学, 先端生命科学研究所, 特任准教授 (80437516)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ペリニューロナルネット / パルブアルブミン / 扁桃体 / cFos / 恐怖条件づけ / 記憶痕跡 / 興奮/抑制バランス / 恐怖記憶消去 / 血管作動性腸管ペプチド / 細胞外マトリックス / 恐怖条件付け / 神経可塑性 / 海馬 |
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| Outline of Final Research Achievements |
Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods of brain function and synaptic plasticity. However, in some specific brain regions such as the amygdala, PNNs were predominantly expressed around excitatory neurons. These neurons were recruited during auditory fear conditioning and memory retrieval. Indeed, the activation of PNN-expressing excitatory neurons predicted cognitive performance.
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Report
(4 results)
Research Products
(10 results)
