Manipulation of the activity of parvalbumin-expressing interneurons against post-traumatic stress disorder

• Project/Area Number: 15K06784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Hoshi University
• Principal Investigator: Tamura Hideki 星薬科大学, 先端生命科学研究所, 特任准教授 (80437516)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ペリニューロナルネット / パルブアルブミン / 扁桃体 / cFos / 恐怖条件づけ / 記憶痕跡 / 興奮/抑制バランス / 恐怖記憶消去 / 血管作動性腸管ペプチド / 細胞外マトリックス / 恐怖条件付け / 神経可塑性 / 海馬

Outline of Final Research Achievements

Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods of brain function and synaptic plasticity. However, in some specific brain regions such as the amygdala, PNNs were predominantly expressed around excitatory neurons. These neurons were recruited during auditory fear conditioning and memory retrieval. Indeed, the activation of PNN-expressing excitatory neurons predicted cognitive performance.

Research Products

• [Journal Article] Trophic modulation of gamma oscillations: The key role of processing protease for Neuregulin-1 and BDNF precursors (2017)
  • Author(s): Tamura H, Shiosaka S, Morikawa S
  • Journal Title: Neurochemistry International Volume: 17 Pages: 30461-30468
  • DOI: 10.1016/j.neuint.2017.12.002
  • Peer Reviewed
• [Journal Article] Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation (2017)
  • Author(s): Kawata M, Morikawa S, Shiosaka S, Tamura H
  • Journal Title: Translational Psychiatry Volume: 7 Issue: 3 Pages: e1052-e1052
  • DOI: 10.1038/tp.2017.20
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval (2017)
  • Author(s): Morikawa S, Ikegaya Y, Narita M, Tamura H
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 46024-46024
  • DOI: 10.1038/srep46024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ニューロプシンによる海馬認知機能の制御 (2016)
  • Author(s): 田村 英紀、塩坂 貞夫
  • Journal Title: 脳21 Volume: 19 Pages: 20-25
• [Journal Article] ニューロプシンによる統合失調症脆弱因子Neuregulin-1 のプロセシングを介した抑制性ニューロンの制御機構 (2015)
  • Author(s): 田村 英紀
  • Journal Title: 日本生物学的精神医学会誌 Volume: 26 Pages: 187-191
  • NAID: 130005395619
• [Journal Article] 痛みと情動障害：痛みの細胞記憶 (2015)
  • Author(s): 成田 年、渡邉 萌、濱田 祐輔、田村 英紀、池上 大悟、葛巻 直子、五十嵐 勝秀
  • Journal Title: Japanese Journal of Neuropsychopharmacology Volume: 35 Pages: 89-95
• [Presentation] Activation of perineuronal net-positive excitatory neurons during associative memory learning (2017)
  • Author(s): 森川勝太、池谷裕二、成田年、田村英紀
  • Organizer: 第60回 日本神経化学会大会
• [Presentation] マウス海馬 CA2 野におけるペリニューロナルネットの形成 (2016)
  • Author(s): 野口 朝子、松本 信圭、田村 英紀、池谷 裕二
  • Organizer: 第25 回海馬と高次能機能学会
  • Place of Presentation: 同志社大学室町キャンパス寒梅館,京都府京都市
  • Year and Date: 2016-10-01
• [Presentation] 統合失調症に関与する新しい抑制性神経ネットワーク制御機構 (2016)
  • Author(s): 河田 美穂、田村 英紀、葛巻 直子、成田 道子、塩坂 貞夫、成田 年
  • Organizer: 第89 回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜、神奈川県横浜市
  • Year and Date: 2016-03-09
• [Presentation] Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation (2015)
  • Author(s): 森川 勝太、河田 美穂、塩坂 貞夫、田村 英紀
  • Organizer: 第58 回日本神経化学会大会
  • Place of Presentation: 大宮ソニックシティ、埼玉県大宮市
  • Year and Date: 2015-09-11