| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
The GDF5 gene is reported to be associated with osteoarthritis (OA) in mice and humans. M451 mouse strain, which possesses the missense mutation (W408R) in Gdf5, develops an early-onset osteoarthritis (OA) of the elbow joint. However, detailed evaluation of M451 strain as OA model animals has not been carried out. We generated congenic mouse strains in which W408R mutation was introduced into the genetic background C57BL/6 or STR/ort. We confirmed the duplicability of an early-onset OA in the C57BL/6 congenic strain. Articular cartilage lesion in the STR/ort congenic strain seemed more severe than that that in STR/ort. These two congenic strains are useful to develop novel OA model animals.
|
