| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we tried to elucidate the pathogenesis of diabetes in the novel animal model of obese type 2 diabetes, the Zucker fatty diabetes mellitus (ZFDM) rat. By insulin secretion experiment, transcriptome analysis, metabolome analysis, and western blotting of isolated pancreatic islets, we found that the number of large islets increased with age and insulin secretion was impaired in the large islets. We also found that glycolysis and hexosamine biosynthesis pathways were enhanced and downstream O-GlcNAcylation of proteins was increased in the large islets. These findings may underlie the elucidation of pathogenesis of diabetes and development of drugs based on the novel mechanism.
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