Elucidation of pathogenesis of diabetes in the novel obese diabetes model ZFDM rat
Project/Area Number |
15K06800
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Kobe University |
Principal Investigator |
YOKOI NORIHIDE 神戸大学, 医学研究科, 特命准教授 (70311610)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 糖尿病 / 疾患モデル / インスリン分泌障害 / メタボローム解析 / 病態発症機構 / インスリン分泌 / 動物モデル / 多因子疾患 |
Outline of Final Research Achievements |
In this study, we tried to elucidate the pathogenesis of diabetes in the novel animal model of obese type 2 diabetes, the Zucker fatty diabetes mellitus (ZFDM) rat. By insulin secretion experiment, transcriptome analysis, metabolome analysis, and western blotting of isolated pancreatic islets, we found that the number of large islets increased with age and insulin secretion was impaired in the large islets. We also found that glycolysis and hexosamine biosynthesis pathways were enhanced and downstream O-GlcNAcylation of proteins was increased in the large islets. These findings may underlie the elucidation of pathogenesis of diabetes and development of drugs based on the novel mechanism.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] A novel diphenylthiosemicarbazide is a potential insulin secretagogue for anti-diabetic agent2016
Author(s)
Sugawara k, Honda K, Reien Y, Yokoi N, Seki C, Takahashi H, Minami K, Mori I, Matsumoto A, Nakaya H, Seino S
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Journal Title
PLoS One
Volume: 11
Issue: 10
Pages: e0164785-e0164785
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 肥満糖尿病の膵島におけるインクレチン応答性障害―オミクス解析による検討―2018
Author(s)
速水智英, 横井伯英, 日高志保美, 川畑綾子, グプルジャン ゲニ, マヒラ アシム, 高橋晴美, 神谷英紀, 清野 裕, 中村二郎, 清野 進
Organizer
第61回日本糖尿病学会年次学術集会
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