Research Project
Grant-in-Aid for Scientific Research (C)
Human T-cell leukemia virus type 1 (HTLV-1) can cause adult T-cell leukemia/lymphoma (ATL). The Tax protein encoded by HTLV-1 appears to be a key element in the early stage of ATL development. We examined the expression of the downstream of tyrosine kinase (Dok) family members Dok-1, Dok-2 and Dok-3, recently reported to be tumor suppressors, in HTLV-1-infected T cells and transgenic mice expressing the tax gene. Dok-2 and Dok-3 expression was significantly reduced in HTLV-1-infected T cells compared with their expression in uninfected T cells, and the expression of Dok-3 was reduced by the induction of Tax expression in T cells. The transgenic mice showed low expression of Dok-1, Dok-2 and Dok-3 in mice with T cell leukemia. Mice showed low Dok-2 expression at 5-6 months of age before disease onset. These results suggest that downregulation of Dok-2 and Dok-3 by the expression of the viral tax gene is the first step in the development of ATL.
All 2018 2017 2016 2015
All Journal Article (6 results) (of which Peer Reviewed: 5 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results, Invited: 1 results)
Journal of Veterinary Medical Science
Volume: 79 Issue: 5 Pages: 935-938
10.1292/jvms.17-0034
130005665593
Acta Virologica
Volume: 60 Issue: 02 Pages: 211-213
10.4149/av_2016_02_211
Japanese Journal of Veterinary Research
Volume: 64 Issue: 2 Pages: 131-139
10.14943/jjvr.64.2.131
120005763158
Volume: -
日本ウイルス学会北海道支部報
Volume: 46 Pages: 2-6
