Developmental mechanisms of glioblastoma-derived blood vessels and their effect on malignancy
| Project/Area Number |
15K06823
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 低酸素 / がん / 血管新生 / 低酸素応答 |
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| Outline of Final Research Achievements |
Glioblastoma (GBM) is a disease with very poor prognosis, because GBM has high proliferative and invasive activities. The microenvironment of tumor is important for these phenomenon. Vascular endothelial cells, which are components of the microenvironment have an important role. For the purpose of functional analysis of endothelial cells, I analyzed the expression of related factors using endothelial cells derived from GBM patients. As a result, the expression of SDF-1 was increased in GBM derived endothelial cells. SDF-1 is specific expressing in pathological endothelial cells, and this factor is respond to hypoxic stimulation. In this research project, I clarified the relation between hypoxic stimulation and endothelial function for tumor environment in the research term.
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Report
(4 results)
Research Products
(9 results)
