| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Anchorage-independent growth is characteristic for cancer cells, but the perspective of its regulatory mechanisms remains unclear. To address this, we focused on the molecule X which has been reported to control anchorage independent growth of cancer cells in vitro and tried to clarify the role of molecule X in vivo, especially in tumor progression. The analyses of X knockout mice revealed that molecule X expressed not only in cancer cells but also in host imuunesuppressive cells and increased the number of immunesuppressive cells. The molecule X also promoted tumor growth and lung metastasis in breast cancer model mice.
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