• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Changes in the binding regions of Smads downstream of TGF-beta signaling in diffuse type gastric cancers

Research Project

Project/Area Number 15K06831
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionThe University of Tokyo

Principal Investigator

Koinuma Daizo  東京大学, 大学院医学系研究科(医学部), 准教授 (80375071)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsシグナル伝達 / 癌 / 転写因子 / TGF-beta / ChIP-seq / スキルス胃がん / がん
Outline of Final Research Achievements

Cytokines of transfroming growth factor-beta (TGF-beta) play important roles in the pathogenesis of diffuse type gastric cancers. We previously reported that TGF-beta and the binding sites of its downstream Smad2/3 transcription factors are deferentially regulated in different types of the cells. We here analyzed our ChIP-seq data of Smad2/3 obtained from several diffuse type gastric cancer cell lines to reveal its regulatory mechanisms. Through comparison with the Smad2/3 binding data of the other cells, we identified a target gene of TGF-beta whose expression was deferentially correlated with the prognosis of patients with gastric cancer. We also found that this target gene regulated cellular motility, suggesting its roles in the progression of cancers.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2015 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] Identification of a novel fusion gene HMGA2-EGFR in glioblastoma2017

    • Author(s)
      Komuro Akiyoshi、Raja Erna、Iwata Caname、Soda Manabu、Isogaya Kazunobu、Yuki Keiko、Ino Yasushi、Morikawa Masato、Todo Tomoki、Aburatani Hiroyuki、Suzuki Hiromichi、Ranjit Melissa、Natsume Atsushi、Mukasa Akitake、Saito Nobuhito、Okada Hitoshi、Mano Hiroyuki、Miyazono Kohei、Koinuma Daizo
    • Journal Title

      International Journal of Cancer

      Volume: 142 Issue: 8 Pages: 1627

    • DOI

      10.1002/ijc.31179

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Integrated analysis of transcriptional regulation by Smads2017

    • Author(s)
      Daizo Koinuma
    • Organizer
      TGF-beta meeting, Uppsala, Sweden
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamics of chromatin accessibility during TGF-beta-induced EMT of Ras-transformed mammary gland epithelial cells2015

    • Author(s)
      Koinuma D, Arase M, Isogaya K, Nakaki R, Mizutani A, TsutsumiS, Aburatani H, Miyazono K
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Genome-wide profiling of TGF-beta-related transcription factor footprints2015

    • Author(s)
      Koinuma D
    • Organizer
      TGF-beta meeting
    • Place of Presentation
      Uppsala(Sweden)
    • Year and Date
      2015-08-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 東京大学大学院医学系研究科分子病理学分野

    • URL

      http://beta-lab.umin.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科分子病理学ホームページ

    • URL

      http://beta-lab.umin.ac.jp/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi