• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Premetastatic niche enhances liver metastasis

Research Project

Project/Area Number 15K06842
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionTokyo Women's Medical University

Principal Investigator

DEGUCHI ATSUKO  東京女子医科大学, 医学部, 助教 (10422932)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝転移 / 微小環境 / 大腸がん / S100A8 / がん微小環境
Outline of Final Research Achievements

During tumor progression, inflammatory signaling develops tumor microenvironment. Similarly, metastatic tumors can prepare a premetastatic niche at their favorable organs. To establish novel therapeutic strategy against liver metastasis, we investigated the mechanism(s) by which hepatic premetastatic niche factor enhance cancer metastasis. We also examined the effect of S100A8 on liver metastasis in mouse models, and found that S100A8 played a role in liver metastasis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Dickkopf-1 helps metastasis by immune evasion2017

    • Author(s)
      Atsuko Deguchi, Yoshiro Maru
    • Journal Title

      Translational Cancer Research

      Volume: 6 Issue: S9 Pages: S1422-S1424

    • DOI

      10.21037/tcr.2017.10.43

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma2016

    • Author(s)
      Imai Y, Ohta E, Takeda S, Sunamura S, Ishibashi M, Tamura H, Wang Y, Deguchi A, Tanaka J, Maru Y, and Motoji,T.
    • Journal Title

      JCI Insight

      Volume: 未定

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment.2016

    • Author(s)
      Deguchi A, Tomita T, Ohto U, Takemura K, Kitao A, Akashi-Takamura, S, Miyake K, and Maru Y.
    • Journal Title

      Oncogene

      Volume: 35 Issue: 11 Pages: 1445-1456

    • DOI

      10.1038/onc.2015.211

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 転移前ニッチ形成を標的とした新規がん治療への展開2018

    • Author(s)
      出口敦子、丸義朗
    • Organizer
      第357回東京女子医科大学学会例会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 胃がん増悪化におけるToll様受容体内因性リガンドの関与2017

    • Author(s)
      出口敦子、大島浩子、大島正伸、丸義朗
    • Organizer
      金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム
    • Place of Presentation
      金沢東急ホテル(石川県金沢市)
    • Year and Date
      2017-02-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 胃がん進展におけるToll様受容体内因性リガンドの作用2017

    • Author(s)
      出口敦子、大島浩子、大島正伸、丸義朗
    • Organizer
      金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Book] Cancer Metastasis and Cancer Stem Cell/Niche2016

    • Author(s)
      Takeshi Tomita, Atsuko Deguchi, Yoshiro Maru
    • Total Pages
      145
    • Publisher
      Bentham Science Publisher
    • Related Report
      2016 Research-status Report
  • [Remarks] 東京女子医科大学薬理学教室ホームページ

    • URL

      http://www.twmu.ac.jp/Basic/yakuri/paper.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京女子医科大学薬理学教室ホームページ

    • URL

      http://www.twmu.ac.jp/Basic/yakuri

    • Related Report
      2016 Research-status Report
  • [Remarks] 東京女子医科大学薬理学教室ホームページ

    • URL

      http://www.twmu.ac.jp/Basic/yakuri/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi