Premetastatic niche enhances liver metastasis

• Project/Area Number: 15K06842
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: DEGUCHI ATSUKO 東京女子医科大学, 医学部, 助教 (10422932)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肝転移 / 微小環境 / 大腸がん / S100A8 / がん微小環境

Outline of Final Research Achievements

During tumor progression, inflammatory signaling develops tumor microenvironment. Similarly, metastatic tumors can prepare a premetastatic niche at their favorable organs. To establish novel therapeutic strategy against liver metastasis, we investigated the mechanism(s) by which hepatic premetastatic niche factor enhance cancer metastasis. We also examined the effect of S100A8 on liver metastasis in mouse models, and found that S100A8 played a role in liver metastasis.

Research Products

• [Journal Article] Dickkopf-1 helps metastasis by immune evasion (2017)
  • Author(s): Atsuko Deguchi, Yoshiro Maru
  • Journal Title: Translational Cancer Research Volume: 6 Issue: S9 Pages: S1422-S1424
  • DOI: 10.21037/tcr.2017.10.43
  • Peer Reviewed / Open Access
• [Journal Article] Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma (2016)
  • Author(s): Imai Y, Ohta E, Takeda S, Sunamura S, Ishibashi M, Tamura H, Wang Y, Deguchi A, Tanaka J, Maru Y, and Motoji,T.
  • Journal Title: JCI Insight Volume: 未定
  • Peer Reviewed
• [Journal Article] Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment. (2016)
  • Author(s): Deguchi A, Tomita T, Ohto U, Takemura K, Kitao A, Akashi-Takamura, S, Miyake K, and Maru Y.
  • Journal Title: Oncogene Volume: 35 Issue: 11 Pages: 1445-1456
  • DOI: 10.1038/onc.2015.211
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 転移前ニッチ形成を標的とした新規がん治療への展開 (2018)
  • Author(s): 出口敦子、丸義朗
  • Organizer: 第357回東京女子医科大学学会例会
  • Invited
• [Presentation] 胃がん増悪化におけるToll様受容体内因性リガンドの関与 (2017)
  • Author(s): 出口敦子、大島浩子、大島正伸、丸義朗
  • Organizer: 金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム
  • Place of Presentation: 金沢東急ホテル(石川県金沢市)
  • Year and Date: 2017-02-14
• [Presentation] 胃がん進展におけるToll様受容体内因性リガンドの作用 (2017)
  • Author(s): 出口敦子、大島浩子、大島正伸、丸義朗
  • Organizer: 金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム
• [Book] Cancer Metastasis and Cancer Stem Cell/Niche (2016)
  • Author(s): Takeshi Tomita, Atsuko Deguchi, Yoshiro Maru
  • Total Pages: 145
  • Publisher: Bentham Science Publisher
• [Remarks] 東京女子医科大学薬理学教室ホームページ
  • URL: http://www.twmu.ac.jp/Basic/yakuri/paper.html
• [Remarks] 東京女子医科大学薬理学教室ホームページ
  • URL: http://www.twmu.ac.jp/Basic/yakuri
• [Remarks] 東京女子医科大学薬理学教室ホームページ
  • URL: http://www.twmu.ac.jp/Basic/yakuri/