Molecular mechanisms of mast cell tumorigenesis process

• Project/Area Number: 15K06843
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Tokyo University of Science
• Principal Investigator: Abe Ryo 東京理科大学, 研究推進機構生命医科学研究所, 教授 (20159453)
• Co-Investigator(Kenkyū-buntansha): 小幡 裕希 東京理科大学, 研究推進機構生命医科学研究所, 講師 (20609408) ; 若松 英 東京理科大学, 研究推進機構生命医科学研究所, 助教 (40632617)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: マスト細胞腫 / Kitチロシンキナーゼ / PI3K-Akt / STAT5 / GIST / オルガネラ / c-Kit / PI3K / Akt / がん / マスト細胞 / 腫瘍化

Outline of Final Research Achievements

Previously, we established mast cell lines from mouse spleen and induced their autonomous proliferation by reducing cytokines that are required for normal mast cell growth. Furthermore, the mast cell line have characteristic features of mastocytoma cells. Thus, this experimental system help us to understand the mechanism of development of mast cell cancer.
In this study, we found that Kit autophosphorylation and activation of Erk and of Akt occur in the early stage of cancerization, whereas STAT5 activation is found only in the late phase. At present, analyses of molecular mechanism of the stage-specific activation of Kit,Erk, Akt, and STAT5 are under way.

Research Products

• [Int'l Joint Research] Harvard University(アメリカ合衆国)
• [Journal Article] Strong TCR stimulation promotes the stabilization of Foxp3 expression in regulatory T cells induced in vitro through increasing the demethylation of Foxp3 CNS2. (2018)
  • Author(s): Wakamatsu, E., Omori, H., Kawano, A. & Abe, R.
  • Journal Title: Mol. Immunol. Volume: -
  • Peer Reviewed
• [Journal Article] CD28 co-stimulation is dispensable for the steady state homeostasis of intestinal regulatory T cells. (2018)
  • Author(s): Wakamatsu E, Omori H, Tabata Y, Akieda Y, Watanabe S, Ogawa S, Abe R.
  • Journal Title: International Immunology Volume: 30 Pages: 171-180
  • DOI: 10.1093/intimm/dxy013
  • Peer Reviewed
• [Journal Article] Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in gastrointestinal stromal tumours (2018)
  • Author(s): Obata Y, Horikawa K, Shiina I, Takahashi T, Murata T, Tasaki Y, Suzuki K, Yonekura K, Esumi H, Nishida T, Abe R
  • Journal Title: Cancer Lett Volume: 415 Pages: 1-10
  • DOI: 10.1016/j.canlet.2017.11.032
  • Peer Reviewed / Open Access
• [Journal Article] Size-Based Differentiation of Cancer and Normal Cells by a Particle Size Analyzer Assisted by a Cell-Recognition PC Software (2018)
  • Author(s): Babita Shashni, Shinya Ariyasu, Reisa Takeda, Toshihiro Suzuki, Shota Shiina, Kazunori Akimoto, Takuto Maeda, Naoyuki Aikawa, Ryo Abe, Tomorhiro Osaki, Norihiko Itoh, and Shin Aoki
  • Journal Title: Biol Pharm Bull. Volume: 41 Issue: 4 Pages: 487-503
  • DOI: 10.1248/bpb.b17-00776
  • Peer Reviewed / Open Access
• [Journal Article] Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers. (2018)
  • Author(s): Ohtsuka J, Oshima H, Ezawa I, Abe R, Oshima M, Ohki R.
  • Journal Title: Scientific Report Volume: 8
  • DOI: 10.1038/s41598-018-20572-1
  • Peer Reviewed / Open Access
• [Journal Article] Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques (2018)
  • Author(s): Sakata M, Ohigashi I, Takahama Y.
  • Journal Title: J Immunol. Volume: 200 Pages: 1382-1388
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer. (2017)
  • Author(s): Nozaki Y, Tamori S, Inada M, Katayama R, Nakane H, Minamishima O, Onodera Y, Abe M, Shiina S, Tamura K, Kodama D, Sato K, Hara Y, Abe R, Takasawa R, Yoshimori A, Shinomiya N, Tanuma S, Akimoto K.
  • Journal Title: Genes Cancer Volume: 8 Pages: 628-639
  • DOI: 10.18632/genesandcancer.148
  • Peer Reviewed / Open Access
• [Journal Article] M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the socrotory pathway in nooplastic mast cells (2017)
  • Author(s): Hara Y, Obata Y, Horikawa K, Tasaki Y, Suzuki K, Murata T, Shiina I, Abc R
  • Journal Title: PLoS ONE Volume: -
  • DOI: 10.1371/journal.pone.0175514
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors. (2017)
  • Author(s): Obata, Y., Horikawa, K., Takahashi, T., Akieda, Y., Tsujimoto, M., Fletcher, J.A., Esumi, H., Nishida, T. & Abe, R.
  • Journal Title: ONCOGENE Volume: -
  • DOI: 10.1038/onc.2016.519
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The spleen is the site where mast cells are induced in the development of food allergy (2017)
  • Author(s): Toyoshima, S., Wakamatsu, E., Ishida, Y., Obata, Y., Kurashima, Y., Kiyono, T. & Abe, R.
  • Journal Title: International Immunology Volume: 29 Pages: 31-45
  • DOI: 10.1093/intimm/dxx005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Radiosensitizing Effect of P2X7 Receptor Antagonist on Melanoma <i>in Vitro</i> and <i>in Vivo</i> (2017)
  • Author(s): Tanamachi K, Nishino K, Mori N, Suzuki T, Tanuma SI, Abe R, Tsukimoto M.
  • Journal Title: Biol Pharm Bull. Volume: Mar 24 Issue: 6 Pages: 1-2
  • DOI: 10.1248/bpb.b17-00083
  • Peer Reviewed / Open Access
• [Journal Article] Cationic amphiphilic tris-cyclometalated iridium(III) complexes induce cancer cell death via interaction with Ca2+-calmodulin complex. (2017)
  • Author(s): Hisamatsu Y, Suzuki N, Masum AA, Shibuya A, Abe R, Sato A, Tanuma SI, Aoki S.
  • Journal Title: Bioconjug. Chem. Volume: 28(2) Pages: 507-523
  • DOI: 10.1021/acs.bioconjchem.6b00627
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells (2016)
  • Author(s): Ohtsuka, S., Ogawa, S., Wakamatsu, E., Abe, R.
  • Journal Title: International Immunology Volume: 11 Pages: 547-557
  • Peer Reviewed
• [Journal Article] Requirement of interleukin-7 signaling for anti-tumor immune response under lymphopenic conditions in a murine lung carcinoma model (2016)
  • Author(s): Suzuki T, Kishimoto H, Abe R.
  • Journal Title: Cancer Immunol. Immun. Volume: 65 Pages: 341-354
  • DOI: 10.1007/s00262-016-1808-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Protective Role of ICOS and ICOS ligand in corneal transplantation and in maintenance of immune privilege (2016)
  • Author(s): Kunishige, T., Taniguchi, H., Terada, M., Akiba, H., Yagita, H., Abe, R. & Hori J.
  • Journal Title: Invest. Ophthalmol. Vis. Sci Volume: 57 Pages: 6815-6823
  • Peer Reviewed
• [Journal Article] Structures and thermodynamic analysis reveal distinct mechanisms of CD28 phosphopeptide binding to the SH2 domains of three adaptor proteins (2016)
  • Author(s): Inaba, S., Numoto, N., Ogawa, S., Morii, H., Ikura, T., Abe, R., Ito, N. & Oda M.
  • Journal Title: J. Biol. Chem. Volume: 292 Pages: 1052-1060
  • DOI: 10.1074/jbc.m116.755173
  • Peer Reviewed
• [Journal Article] 11B NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Derivatives (2016)
  • Author(s): Tanaka,T., Nishiura, Y., Araki, R., Saido, T., Abe, R. & Aoki, S.
  • Journal Title: Eur. J. Inorg. Chem. Volume: 12 Pages: 1819-1834
  • Peer Reviewed
• [Journal Article] 11B NMR/MRI Sensing of Copper(II) Ions In Vitro by the Decomposition of a Hybrid Compound of a nido-o-Carborane and a Metal Chelator.” (2016)
  • Author(s): Tanaka, T., Araki, R., Saido, T., Abe, R. & Aoki, S.
  • Journal Title: Eur. J. Inorg. Chem.3330-3337 Volume: 20 Pages: 3330-3337
  • Peer Reviewed
• [Journal Article] IL-1 Receptor Signaling on Graft Parenchymal Cells Regulates Memory and De Novo Donor-Reactive CD8 T Cell Responses to Cardiac Allografts. (2016)
  • Author(s): Iida S, Tsuda H, Tanaka T, Kish DD, Abe T, Su CA, Abe R, Tanabe K, Valujskikh A, Baldwin WM 3rd, Fairchild RL.
  • Journal Title: J. Immunol. Volume: 196 Pages: 2827-2837
  • DOI: 10.4049/jimmunol.1500876
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An enhancer of the IL-7 receptor α-chain locus controls IL-7 receptor expression and maintenance of peripheral T cells (2015)
  • Author(s): Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, Ikuta K.
  • Journal Title: The Journal of Immunology Volume: 195 Pages: 3129-3138
  • DOI: 10.4049/jimmunol.1302447
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma. (2015)
  • Author(s): Makinoshima H, Takita M, Saruwatari K, Umemura S, Obata Y, Ishii G, Matsumoto S, Sugiyama E, Ochiai A, Abe R, Goto K, Esumi H, Tsuchihara K.
  • Journal Title: J. Biol. Chem. Volume: 290 Pages: 17495-17504
  • DOI: 10.1074/jbc.m115.660498
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enrichment of Circulating Tumor Cells in Tumor-bearing Mouse Blood by a Deterministic Lateral Displacement Microfluidic Device (2015)
  • Author(s): Okano H, Konishi T, Suzuki T, Suzuki T, Ariyasu S, Aoki S, Abe R, Hayase M.
  • Journal Title: Biomedical Microdevices Volume: 17 Pages: 1-17
  • DOI: 10.1007/s10544-015-9964-7
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Design and Synthesis of Amphiphilic and Luminescent Tris-Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Inducers and Detectors of Cell Death via a Calcium-Dependent Pathway (2015)
  • Author(s): Hisamatsu Y, Shibuya A, Suzuki N, Suzuki T, Abe R, Aoki S
  • Journal Title: Bioconjug. Chem. Volume: 26 Pages: 857-879
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Defects in regulatory T cells due to CD28 deficiency induce a qualitative change of allogeneic immune response in chronic graft-versus-host disease (2015)
  • Author(s): Akieda Y, Wakamatsu E, Nakamura T, Ishida Y, Ogawa S, Abe R
  • Journal Title: J. Immunol. Volume: 194 Pages: 4162-4174
  • DOI: 10.4049/jimmunol.1402591
  • Peer Reviewed / Int'l Joint Research
• [Presentation] The regulation of CD28 tyrosine phosphorylation and the function of CD28-mediated costimulation. (2017)
  • Author(s): 小川修平, 渡辺志帆, 安部 良
  • Organizer: The 46th Annual Meeting of the Japanese society of Immunology
• [Presentation] IL-2 production is negatively regulated by free fatty acid receptor 2 (Ffar2) mediated signaling. (2017)
  • Author(s): 田畑由紀, 小川修平, 若松 英, 渡辺志帆, 安部 良
  • Organizer: The 46th Annual Meeting of the Japanese society of Immunology
• [Presentation] マスト細胞腫・GISTにおけるKitチロシンキナーゼの異常局在とオルガネラシグナリング ～がんシグナルの発信源は細胞内小器官にあった～ (2017)
  • Author(s): 小幡裕希, 堀川啓太, 高橋 剛, 原 泰志, 椎名 勇, 江角浩安, 西田俊朗, 安部 良
  • Organizer: 第160回 日本獣医学会学術集会 シンポジウム
  • Invited
• [Presentation] がん抑制遺伝子p53機能喪失を伴った胃がんモデルを用いたの悪性化機能の解明 (2017)
  • Author(s): 大塚旬子、江澤一生、安部 良、大島正伸、大木理恵子
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] イマチニブ耐性Kitの阻害に関する新規戦略: M-COPAによる分泌経路の阻害はマスト細胞腫のエンドリソソームにおけるKitのがんシグナルを抑制する. (2017)
  • Author(s): 原 泰志, 小幡裕希, 堀川啓太, 村田貴嗣, 鈴木恭平, 田﨑靖崇, 椎名 勇, 安部 良
  • Organizer: 2017年度 生命科学系学会 合同年次大会
• [Presentation] マスト細胞白血病・GISTを無限増殖に導くKitチロシンキナーゼのがんシグナルは細胞膜ではなくオルガネラから発信される. (2017)
  • Author(s): 小幡裕希, 堀川啓太, 原 泰志, 椎名 勇, 江角浩安, 西田俊朗, 安部 良
  • Organizer: 第69回 日本細胞生物学会大会
• [Presentation] The responsiveness to TCR stimulation of Treg subsets influences the dependency of their proliferation on CD28 (2017)
  • Author(s): Wakamatsu, E., Omori, H., Ogawa, S. & Abe R.
  • Organizer: 7th International Workshop of Kyoto T Cell Conference
  • Place of Presentation: 京都大学, 京都
  • Year and Date: 2017-03-13
• [Presentation] 消化管間質細胞腫における Kit チロシンキナーゼの異常局在とがんシグナリングの関係 (2016)
  • Author(s): 小幡裕希, 堀川啓太, 穐枝佑紀, 椎名 勇, 江角浩安, 西田俊朗, 安部 良
  • Organizer: 第2回 日本細胞生物学会 若手の会
  • Place of Presentation: テルサ京都, 京都
• [Presentation] The effect of TCR and CD28 stimulation on tyrosine phosphorylation of CD28 (2016)
  • Author(s): Ogawa, S., Watanabe, S., Wakamatsu, E., Ohtsuka, S. & Abe, R.
  • Organizer: The 45th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 沖縄コンベンションセンター, 沖縄
  • Year and Date: 2016-12-05
• [Presentation] 消化管間質細胞腫, マスト細胞腫の無限増殖にはオルガネラでのPI3K-Aktシグナルが必要である ~変異型Kitチロシンキナーゼのゴルジ体, エンド/リソソームへの異常局在とがんシグナリング~ (2016)
  • Author(s): 小幡裕希, 堀川啓太, 高橋 剛, 穐枝佑紀, 辻本正彦, 原 泰志, 江角浩安, 西田俊朗, 安部 良
  • Organizer: 第39回 日本分子生物学会大会
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] 消化管間質細胞腫におけるKitチロシンキナーゼのがんシグナリングは細胞膜ではなくゴルジ体で起こる (2016)
  • Author(s): 堀川啓太, 小幡裕希, 高橋剛, 江角浩安, 西田俊朗, 安部 良
  • Organizer: 第39回 日本分子生物学会大会
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2016-11-30
• [Presentation] カルボラン分解反応を利用した銅(II)イオン検出のための11B NMR/MRIプローブの設計と合成 (2016)
  • Author(s): 田中智博, 西浦由紀子, 荒木力太, 西道隆臣, 安部 良, 青木 伸
  • Organizer: 第42回 反応と合成の進歩シンポジウム
  • Place of Presentation: 清水文化会館マリナート, 静岡
  • Year and Date: 2016-11-07
• [Presentation] Oncogenic signals by Kit tyrosine kinase occur on the Golgi apparatus in gastrointestinal stromal tumor cells ~ Spatiotemporal analyses of imatinib-resistant and -sensitive Kit signaling ~ (2016)
  • Author(s): Obata, Y., Horikawa, K., Takahashi, T., Akieda, Y., Tsujimoto, M., Esumi, H., Nishida, T. & Abe, R.
  • Organizer: The 41st Naito Conference
  • Place of Presentation: ホテルシャトーガトレーゼサッポロ, 札幌
  • Year and Date: 2016-07-05
• [Presentation] Oncogenic signals by Kit tyrosine kinase occur on the Golgi apparatus in gastrointestinal stromal tumor cells (2016)
  • Author(s): Obata, Y., Horikawa, K., Takahashi, T., Akieda, Y., Tsujimoto, M., Esumi, H., Nishida, T & Abe, R.
  • Organizer: The 41st Naito Conference
  • Place of Presentation: 札幌, シャトレーゼガトーキングダムサッポロ
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] 消化管間質細胞腫におけるKitチロシンキナーゼの異常局在: ゴルジ体に限局したがんシグナリング (2016)
  • Author(s): 小幡裕希, 堀川啓太, 高橋 剛, 穐枝佑紀, 辻本正彦, 江角浩安, 西田俊朗, 安部 良
  • Organizer: 第68回 日本細胞生物学会大会
  • Place of Presentation: テルサ京都, 京都
  • Year and Date: 2016-06-15
• [Presentation] 細胞増殖へのCD28シグナルの効果は制御性T細胞サブセット間で異なる (2016)
  • Author(s): 若松英, 大森宏樹, 田畑由紀, 小川修平, 安部 良
  • Organizer: 第26回 Kyoto T Cell Conference
  • Place of Presentation: 比叡山延暦寺会館, 大津
  • Year and Date: 2016-05-20
• [Presentation] Mislocalized activation of oncogenic receptors ~ Oncogenic Kit signalling from intracellular compartments in neoplastic mast cells ~ (2016)
  • Author(s): Obata, Y., Toyoshima, S., Horikawa, K., Nishida, T., Esumi H. & Abe, R.
  • Organizer: The International Postgraduate Conference on Pharmaceutical Science 2016
  • Place of Presentation: 千葉, 東京理科大学
  • Year and Date: 2016-02-27
  • Int'l Joint Research / Invited
• [Presentation] Activated T cells control the pathogenic mast cells under allergic conditions (2015)
  • Author(s): Toyoshima, S., Wakamatsu, E., Obata, Y., Ogawa, S. & Abe, R.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 札幌, 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] CD28 makes different impacts on thymus-and peripherally-derived regulatory T cell for their maintenance (2015)
  • Author(s): Wakamatsu, E., Ohmori, H., Ogawa, S. & Abe, R.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 札幌, 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] CD28 co-stimulation is dispensable for the development of peripherally-derived regulatory T cells (2015)
  • Author(s): Ohmori, H., Wakamatsu, E., Kawano, A., Tabata, Y., Ogawa, S. & Abe, R.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 札幌, 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] Differential roles of CD28 YMNM and PYAP motifs in acute GVHD induction (2015)
  • Author(s): Ogawa, S., Watanabe, S., Wakamatsu, E., Ohtsuka, S. & Abe, R.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 札幌, 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] MEK/ERK signaling negatively regulates cell cycle progression of effector T cells following an excessive antigenic stimulation (2015)
  • Author(s): Ohtsuka, S., Watanabe, S., Ogawa, S. & Abe, R.
  • Organizer: The 44th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 札幌, 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] Oncogenic Kit signals on intracellular compartments are required for neoplastic mast cell proliferation (2015)
  • Author(s): 小幡裕希, 豊島翔太, 堀川啓太, 若松 英, 小川修平, 西田俊朗, 江角浩安, 安部 良
  • Organizer: 第3回ブリストル血液アカデミー
  • Place of Presentation: 札幌, 京王プラザホテル札幌
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] Structural and thermodynamic analysis of co-stimulation receptor CD28 phosphopeptide interactions with Grb2, Gads, and PI3-kinese SH2 domains (2015)
  • Author(s): Inaba, S., Numoto, N., Morii, H., Ikura, T., Abe, R., Ito, N. & Oda, M.
  • Organizer: The 29th Annual Symposium of The Protein Society
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-07-22
  • Int'l Joint Research
• [Presentation] Separation of cells using two-step dielectrophoresis (2015)
  • Author(s): Tsujimori, M., Shimizu, T., Kameya, Y., Suzuki, T., Abe, R. & Motosuke, M.
  • Organizer: 7th International Symposium on Microchemistry and Microsystems (ISMM)
  • Place of Presentation: 京都, 京都大学
  • Year and Date: 2015-06-09
  • Int'l Joint Research
• [Presentation] Role of CD28 co-stimulation in the homeostasis of peripherally derived regulatory T cells (2015)
  • Author(s): Wakamatsu,E., Omori,H., Akieda,Y., Ogawa,S. & Abe, R.
  • Organizer: Kyoto T cell Conference 第25回学術集会
  • Place of Presentation: 京都, 京都大学
  • Year and Date: 2015-05-15
• [Presentation] MEK/ERK signaling pathway has differential effects on effector T cell clonal expansion depended on the strength of antigenic stimulation (2015)
  • Author(s): Ohtsuka,S., Ogawa,S., Abe,R
  • Organizer: Kyoto T cell Conference 第25回学術集会
  • Place of Presentation: 京都, 京都大学
  • Year and Date: 2015-05-15
• [Presentation] CD28 cosimulation is required for the maintenance but not the development of peripherally derived regulatory T cells (2015)
  • Author(s): Wakamatsu, E., Akieda, Y., Ohmori, H. & Abe, R.
  • Organizer: Keystone symposia, T Cells: Regultion and Effector Function (D3)
  • Place of Presentation: Snowbird, utah
  • Year and Date: 2015-04-01
  • Int'l Joint Research
• [Presentation] Differential effects of MEK/ERK signaling pathway on the clonal expansion of effector CD4+ T cells (2015)
  • Author(s): Ohtsuka,S., Ogawa, S. & Abe, R.
  • Organizer: Keystone symposia, T Cells: Regultion and Effector Function (D3)
  • Place of Presentation: Snowbird, utah
  • Year and Date: 2015-04-01
  • Int'l Joint Research
• [Book] 臨床免疫・アレルギー科, マスト細胞をがん化に導くKitのシグナル伝達は細胞膜ではなく「エンドリソソーム」, 「小胞体」で起こる (2015)
  • Author(s): 小幡裕希、豊島翔太、若松 英、小川修平、江角浩安、安部 良
  • Publisher: 科学評論社
• [Book] 理大 科学フォーラム 「マスト細胞のがん化シグナリングは細胞内小器官で起こる」 (2015)
  • Author(s): 小幡裕希
  • Publisher: 理大 科学フォーラム
• [Remarks] 東京理科大学 生命医科学研究所 免疫生物学研究部門
  • URL: http://tus-ribsjm.clsv.jp/immunology/
• [Remarks] 東京理科大学 生命医科学研究所 免疫生物学研究部門 安部研究室
  • URL: http://www.ribs.tus.ac.jp/immunology/
• [Remarks] 東京理科大学 生命医科学研究所
  • URL: http://www.ribs.tus.ac.jp