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Molecular mechanisms of mast cell tumorigenesis process

Research Project

Project/Area Number 15K06843
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionTokyo University of Science

Principal Investigator

Abe Ryo  東京理科大学, 研究推進機構生命医科学研究所, 教授 (20159453)

Co-Investigator(Kenkyū-buntansha) 小幡 裕希  東京理科大学, 研究推進機構生命医科学研究所, 講師 (20609408)
若松 英  東京理科大学, 研究推進機構生命医科学研究所, 助教 (40632617)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsマスト細胞腫 / Kitチロシンキナーゼ / PI3K-Akt / STAT5 / GIST / オルガネラ / c-Kit / PI3K / Akt / がん / マスト細胞 / 腫瘍化
Outline of Final Research Achievements

Previously, we established mast cell lines from mouse spleen and induced their autonomous proliferation by reducing cytokines that are required for normal mast cell growth. Furthermore, the mast cell line have characteristic features of mastocytoma cells. Thus, this experimental system help us to understand the mechanism of development of mast cell cancer.
In this study, we found that Kit autophosphorylation and activation of Erk and of Akt occur in the early stage of cancerization, whereas STAT5 activation is found only in the late phase. At present, analyses of molecular mechanism of the stage-specific activation of Kit,Erk, Akt, and STAT5 are under way.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (59 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (24 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 24 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (29 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results) Book (2 results) Remarks (3 results)

  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Strong TCR stimulation promotes the stabilization of Foxp3 expression in regulatory T cells induced in vitro through increasing the demethylation of Foxp3 CNS2.2018

    • Author(s)
      Wakamatsu, E., Omori, H., Kawano, A. & Abe, R.
    • Journal Title

      Mol. Immunol.

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD28 co-stimulation is dispensable for the steady state homeostasis of intestinal regulatory T cells.2018

    • Author(s)
      Wakamatsu E, Omori H, Tabata Y, Akieda Y, Watanabe S, Ogawa S, Abe R.
    • Journal Title

      International Immunology

      Volume: 30 Issue: 4 Pages: 171-180

    • DOI

      10.1093/intimm/dxy013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in gastrointestinal stromal tumours.2018

    • Author(s)
      Obata Y, Horikawa K, Shiina I, Takahashi T, Murata T, Tasaki Y, Suzuki K, Yonekura K, Esumi H, Nishida T, Abe R
    • Journal Title

      Cancer Lett.

      Volume: 415 Pages: 1-10

    • DOI

      10.1016/j.canlet.2017.11.032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Size-Based Differentiation of Cancer and Normal Cells by a Particle Size Analyzer Assisted by a Cell-Recognition PC Software2018

    • Author(s)
      Shashni B, Ariyasu S, Takeda R, Suzuki T, Shiina S, Akimoto K, Maeda T, Aikawa N, Abe R, Osaki T, Itoh N, Aoki S.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 4 Pages: 487-503

    • DOI

      10.1248/bpb.b17-00776

    • NAID

      130006602538

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers.2018

    • Author(s)
      Ohtsuka J, Oshima H, Ezawa I, Abe R, Oshima M, Ohki R.
    • Journal Title

      Scientific Report

      Volume: 8 Issue: 1 Pages: 2291-2291

    • DOI

      10.1038/s41598-018-20572-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer2017

    • Author(s)
      Nozaki Y, Tamori S, Inada M, Katayama R, Nakane H, Minamishima O, Onodera Y, Abe M, Shiina S, Tamura K, Kodama D, Sato K, Hara Y, Abe R, Takasawa R, Yoshimori A, Shinomiya N, Tanuma S, Akimoto K.
    • Journal Title

      Genes & Cancer

      Volume: 8 Issue: 7-8 Pages: 628-639

    • DOI

      10.18632/genesandcancer.148

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells2017

    • Author(s)
      Hara, Y., Obata, Y., Horikawa, K., Tasaki, Y., Suzuki, K., Murata, T., Shiina, I. & Abe, R.
    • Journal Title

      PLoS ONE

      Volume: - Issue: 4 Pages: e0175514-e0175514

    • DOI

      10.1371/journal.pone.0175514

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors2017

    • Author(s)
      Obata, Y., Horikawa, K., Takahashi, T., Akieda, Y., Tsujimoto, M., Fletcher, J.A., Esumi, H., Nishida, T. & Abe, R.
    • Journal Title

      Oncogene

      Volume: - Issue: 26 Pages: 3661-3672

    • DOI

      10.1038/onc.2016.519

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The spleen is the site where mast cells are induced in the development of food allergy2017

    • Author(s)
      Toyoshima, S., Wakamatsu, E., Ishida, Y., Obata, Y., Kurashima, Y., Kiyono, T. & Abe, R.
    • Journal Title

      International Immunology

      Volume: 29 Issue: 1 Pages: 31-45

    • DOI

      10.1093/intimm/dxx005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Radiosensitizing Effect of P2X7 Receptor Antagonist on Melanoma <i>in Vitro</i> and <i>in Vivo</i>2017

    • Author(s)
      Tanamachi K, Nishino K, Mori N, Suzuki T, Tanuma SI, Abe R, Tsukimoto M.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 6 Pages: 878-887

    • DOI

      10.1248/bpb.b17-00083

    • NAID

      130005688046

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cationic Amphiphilic Tris-Cyclometalated Iridium(III) Complexes Induce Cancer Cell Death via Interaction with Ca2+-Calmodulin Complex.2017

    • Author(s)
      Hisamatsu Y, Suzuki N, Masum AA, Shibuya A, Abe R, Sato A, Tanuma SI, Aoki S.
    • Journal Title

      Bioconjug Chem

      Volume: 28(2) Issue: 2 Pages: 507-523

    • DOI

      10.1021/acs.bioconjchem.6b00627

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells2016

    • Author(s)
      Ohtsuka, S., Ogawa, S., Wakamatsu, E., Abe, R.
    • Journal Title

      International Immunology

      Volume: 11 Pages: 547-557

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Requirement of interleukin 7 signaling for anti-tumor immune response under lymphopenic conditions in a murine lung carcinoma model2016

    • Author(s)
      Suzuki T, Kishimoto H, Abe R.
    • Journal Title

      Cancer Immunol. Immunother.

      Volume: 65 Issue: 3 Pages: 341-354

    • DOI

      10.1007/s00262-016-1808-7

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protective Role of ICOS and ICOS ligand in corneal transplantation and in maintenance of immune privilege2016

    • Author(s)
      Kunishige, T., Taniguchi, H., Terada, M., Akiba, H., Yagita, H., Abe, R. & Hori J.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci

      Volume: 57 Pages: 6815-6823

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structures and thermodynamic analysis reveal distinct mechanisms of CD28 phosphopeptide binding to the SH2 domains of three adaptor proteins2016

    • Author(s)
      Inaba, S., Numoto, N., Ogawa, S., Morii, H., Ikura, T., Abe, R., Ito, N. & Oda M.
    • Journal Title

      J. Biol. Chem.

      Volume: 292 Issue: 3 Pages: 1052-1060

    • DOI

      10.1074/jbc.m116.755173

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 11B NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Derivatives2016

    • Author(s)
      Tanaka,T., Nishiura, Y., Araki, R., Saido, T., Abe, R. & Aoki, S.
    • Journal Title

      Eur. J. Inorg. Chem.

      Volume: 12 Pages: 1819-1834

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 11B NMR/MRI Sensing of Copper(II) Ions In Vitro by the Decomposition of a Hybrid Compound of a nido-o-Carborane and a Metal Chelator.”2016

    • Author(s)
      Tanaka, T., Araki, R., Saido, T., Abe, R. & Aoki, S.
    • Journal Title

      Eur. J. Inorg. Chem.3330-3337

      Volume: 20 Pages: 3330-3337

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-1 receptor signaling on graft parenchymal cells regulates memory and de novo donor-reactive CD8 T cell responses to cardiac allografts2016

    • Author(s)
      Iida, S., Tsuda, H., Tanaka, T., Kish, D.D., Abe, T., Su, C.A., Abe, R., Tanabe, K., Valujskikh, A., Baldwin, W.M. 3rd, Fairchild, R.L.
    • Journal Title

      J. Immunol.

      Volume: 196 Pages: 2827-2837

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IL-1 Receptor Signaling on Graft Parenchymal Cells Regulates Memory and De Novo Donor-Reactive CD8 T Cell Responses to Cardiac Allografts.2016

    • Author(s)
      Iida S, Tsuda H, Tanaka T, Kish DD, Abe T, Su CA, Abe R, Tanabe K, Valujskikh A, Baldwin WM 3rd, Fairchild RL.
    • Journal Title

      J. Immunol.

      Volume: 196 Issue: 6 Pages: 2827-2837

    • DOI

      10.4049/jimmunol.1500876

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells.2015

    • Author(s)
      Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, Ikuta K.
    • Journal Title

      J. Immunol.

      Volume: 195 Issue: 7 Pages: 3129-3138

    • DOI

      10.4049/jimmunol.1302447

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.2015

    • Author(s)
      Makinoshima H, Takita M, Saruwatari K, Umemura S, Obata Y, Ishii G, Matsumoto S, Sugiyama E, Ochiai A, Abe R, Goto K, Esumi H, Tsuchihara K.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 28 Pages: 17495-17504

    • DOI

      10.1074/jbc.m115.660498

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enrichment of circulating tumor cells in tumor-bearing mouse blood by a deterministic lateral displacement microfluidic device.2015

    • Author(s)
      Okano H, Konishi T, Suzuki T, Suzuki T, Ariyasu S, Aoki S, Abe R, Hayase M.
    • Journal Title

      Biomed. Microdevices

      Volume: 17 Issue: 3 Pages: 9964-9964

    • DOI

      10.1007/s10544-015-9964-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and Synthesis of Amphiphilic and Luminescent Tris-Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Inducers and Detectors of Cell Death via a Calcium-Dependent Pathway2015

    • Author(s)
      Hisamatsu Y, Shibuya A, Suzuki N, Suzuki T, Abe R, Aoki S
    • Journal Title

      Bioconjug. Chem.

      Volume: 26 Pages: 857-879

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Defects in regulatory T cells due to CD28 deficiency induce a qualitative change of allogeneic immune response in chronic graft-versus-host disease2015

    • Author(s)
      Akieda Y, Wakamatsu E, Nakamura T, Ishida Y, Ogawa S, Abe R
    • Journal Title

      J. Immunol.

      Volume: 194 Issue: 9 Pages: 4162-4174

    • DOI

      10.4049/jimmunol.1402591

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] The responsiveness to TCR stimulation of Treg subsets influences the dependency of their proliferation on CD282017

    • Author(s)
      Wakamatsu, E., Omori, H., Ogawa, S. & Abe R.
    • Organizer
      7th International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      京都大学, 京都
    • Year and Date
      2017-03-13
    • Related Report
      2016 Research-status Report
  • [Presentation] The regulation of CD28 tyrosine phosphorylation and the function of CD28-mediated costimulation.2017

    • Author(s)
      小川修平, 渡辺志帆, 安部 良
    • Organizer
      The 46th Annual Meeting of the Japanese society of Immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] IL-2 production is negatively regulated by free fatty acid receptor 2 (Ffar2) mediated signaling.2017

    • Author(s)
      田畑由紀, 小川修平, 若松 英, 渡辺志帆, 安部 良
    • Organizer
      The 46th Annual Meeting of the Japanese society of Immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] マスト細胞腫・GISTにおけるKitチロシンキナーゼの異常局在とオルガネラシグナリング ~がんシグナルの発信源は細胞内小器官にあった~2017

    • Author(s)
      小幡裕希, 堀川啓太, 高橋 剛, 原 泰志, 椎名 勇, 江角浩安, 西田俊朗, 安部 良
    • Organizer
      第160回 日本獣医学会学術集会 シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] がん抑制遺伝子p53機能喪失を伴った胃がんモデルを用いたの悪性化機能の解明2017

    • Author(s)
      大塚旬子、江澤一生、安部 良、大島正伸、大木理恵子
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イマチニブ耐性Kitの阻害に関する新規戦略: M-COPAによる分泌経路の阻害はマスト細胞腫のエンドリソソームにおけるKitのがんシグナルを抑制する.2017

    • Author(s)
      原 泰志, 小幡裕希, 堀川啓太, 村田貴嗣, 鈴木恭平, 田﨑靖崇, 椎名 勇, 安部 良
    • Organizer
      2017年度 生命科学系学会 合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マスト細胞白血病・GISTを無限増殖に導くKitチロシンキナーゼのがんシグナルは細胞膜ではなくオルガネラから発信される.2017

    • Author(s)
      小幡裕希, 堀川啓太, 原 泰志, 椎名 勇, 江角浩安, 西田俊朗, 安部 良
    • Organizer
      第69回 日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The effect of TCR and CD28 stimulation on tyrosine phosphorylation of CD282016

    • Author(s)
      Ogawa, S., Watanabe, S., Wakamatsu, E., Ohtsuka, S. & Abe, R.
    • Organizer
      The 45th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター, 沖縄
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 消化管間質細胞腫, マスト細胞腫の無限増殖にはオルガネラでのPI3K-Aktシグナルが必要である ~変異型Kitチロシンキナーゼのゴルジ体, エンド/リソソームへの異常局在とがんシグナリング~2016

    • Author(s)
      小幡裕希, 堀川啓太, 高橋 剛, 穐枝佑紀, 辻本正彦, 原 泰志, 江角浩安, 西田俊朗, 安部 良
    • Organizer
      第39回 日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 消化管間質細胞腫におけるKitチロシンキナーゼのがんシグナリングは細胞膜ではなくゴルジ体で起こる2016

    • Author(s)
      堀川啓太, 小幡裕希, 高橋剛, 江角浩安, 西田俊朗, 安部 良
    • Organizer
      第39回 日本分子生物学会大会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] カルボラン分解反応を利用した銅(II)イオン検出のための11B NMR/MRIプローブの設計と合成2016

    • Author(s)
      田中智博, 西浦由紀子, 荒木力太, 西道隆臣, 安部 良, 青木 伸
    • Organizer
      第42回 反応と合成の進歩シンポジウム
    • Place of Presentation
      清水文化会館マリナート, 静岡
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Oncogenic signals by Kit tyrosine kinase occur on the Golgi apparatus in gastrointestinal stromal tumor cells ~ Spatiotemporal analyses of imatinib-resistant and -sensitive Kit signaling ~2016

    • Author(s)
      Obata, Y., Horikawa, K., Takahashi, T., Akieda, Y., Tsujimoto, M., Esumi, H., Nishida, T. & Abe, R.
    • Organizer
      The 41st Naito Conference
    • Place of Presentation
      ホテルシャトーガトレーゼサッポロ, 札幌
    • Year and Date
      2016-07-05
    • Related Report
      2016 Research-status Report
  • [Presentation] Oncogenic signals by Kit tyrosine kinase occur on the Golgi apparatus in gastrointestinal stromal tumor cells2016

    • Author(s)
      Obata, Y., Horikawa, K., Takahashi, T., Akieda, Y., Tsujimoto, M., Esumi, H., Nishida, T & Abe, R.
    • Organizer
      The 41st Naito Conference
    • Place of Presentation
      札幌, シャトレーゼガトーキングダムサッポロ
    • Year and Date
      2016-07-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 消化管間質細胞腫におけるKitチロシンキナーゼの異常局在: ゴルジ体に限局したがんシグナリング2016

    • Author(s)
      小幡裕希, 堀川啓太, 高橋 剛, 穐枝佑紀, 辻本正彦, 江角浩安, 西田俊朗, 安部 良
    • Organizer
      第68回 日本細胞生物学会大会
    • Place of Presentation
      テルサ京都, 京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 細胞増殖へのCD28シグナルの効果は制御性T細胞サブセット間で異なる2016

    • Author(s)
      若松英, 大森宏樹, 田畑由紀, 小川修平, 安部 良
    • Organizer
      第26回 Kyoto T Cell Conference
    • Place of Presentation
      比叡山延暦寺会館, 大津
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Mislocalized activation of oncogenic receptors ~ Oncogenic Kit signalling from intracellular compartments in neoplastic mast cells ~2016

    • Author(s)
      Obata, Y., Toyoshima, S., Horikawa, K., Nishida, T., Esumi H. & Abe, R.
    • Organizer
      The International Postgraduate Conference on Pharmaceutical Science 2016
    • Place of Presentation
      千葉, 東京理科大学
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 消化管間質細胞腫における Kit チロシンキナーゼの異常局在とがんシグナリングの関係2016

    • Author(s)
      小幡裕希, 堀川啓太, 穐枝佑紀, 椎名 勇, 江角浩安, 西田俊朗, 安部 良
    • Organizer
      第2回 日本細胞生物学会 若手の会
    • Place of Presentation
      テルサ京都, 京都
    • Related Report
      2016 Research-status Report
  • [Presentation] Activated T cells control the pathogenic mast cells under allergic conditions2015

    • Author(s)
      Toyoshima, S., Wakamatsu, E., Obata, Y., Ogawa, S. & Abe, R.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌, 札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] CD28 makes different impacts on thymus-and peripherally-derived regulatory T cell for their maintenance2015

    • Author(s)
      Wakamatsu, E., Ohmori, H., Ogawa, S. & Abe, R.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌, 札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] CD28 co-stimulation is dispensable for the development of peripherally-derived regulatory T cells2015

    • Author(s)
      Ohmori, H., Wakamatsu, E., Kawano, A., Tabata, Y., Ogawa, S. & Abe, R.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌, 札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Differential roles of CD28 YMNM and PYAP motifs in acute GVHD induction2015

    • Author(s)
      Ogawa, S., Watanabe, S., Wakamatsu, E., Ohtsuka, S. & Abe, R.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌, 札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] MEK/ERK signaling negatively regulates cell cycle progression of effector T cells following an excessive antigenic stimulation2015

    • Author(s)
      Ohtsuka, S., Watanabe, S., Ogawa, S. & Abe, R.
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌, 札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Oncogenic Kit signals on intracellular compartments are required for neoplastic mast cell proliferation2015

    • Author(s)
      小幡裕希, 豊島翔太, 堀川啓太, 若松 英, 小川修平, 西田俊朗, 江角浩安, 安部 良
    • Organizer
      第3回ブリストル血液アカデミー
    • Place of Presentation
      札幌, 京王プラザホテル札幌
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Structural and thermodynamic analysis of co-stimulation receptor CD28 phosphopeptide interactions with Grb2, Gads, and PI3-kinese SH2 domains2015

    • Author(s)
      Inaba, S., Numoto, N., Morii, H., Ikura, T., Abe, R., Ito, N. & Oda, M.
    • Organizer
      The 29th Annual Symposium of The Protein Society
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-07-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Separation of cells using two-step dielectrophoresis2015

    • Author(s)
      Tsujimori, M., Shimizu, T., Kameya, Y., Suzuki, T., Abe, R. & Motosuke, M.
    • Organizer
      7th International Symposium on Microchemistry and Microsystems (ISMM)
    • Place of Presentation
      京都, 京都大学
    • Year and Date
      2015-06-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of CD28 co-stimulation in the homeostasis of peripherally derived regulatory T cells2015

    • Author(s)
      Wakamatsu,E., Omori,H., Akieda,Y., Ogawa,S. & Abe, R.
    • Organizer
      Kyoto T cell Conference 第25回学術集会
    • Place of Presentation
      京都, 京都大学
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] MEK/ERK signaling pathway has differential effects on effector T cell clonal expansion depended on the strength of antigenic stimulation2015

    • Author(s)
      Ohtsuka,S., Ogawa,S., Abe,R
    • Organizer
      Kyoto T cell Conference 第25回学術集会
    • Place of Presentation
      京都, 京都大学
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] CD28 cosimulation is required for the maintenance but not the development of peripherally derived regulatory T cells2015

    • Author(s)
      Wakamatsu, E., Akieda, Y., Ohmori, H. & Abe, R.
    • Organizer
      Keystone symposia, T Cells: Regultion and Effector Function (D3)
    • Place of Presentation
      Snowbird, utah
    • Year and Date
      2015-04-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Differential effects of MEK/ERK signaling pathway on the clonal expansion of effector CD4+ T cells2015

    • Author(s)
      Ohtsuka,S., Ogawa, S. & Abe, R.
    • Organizer
      Keystone symposia, T Cells: Regultion and Effector Function (D3)
    • Place of Presentation
      Snowbird, utah
    • Year and Date
      2015-04-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 臨床免疫・アレルギー科, マスト細胞をがん化に導くKitのシグナル伝達は細胞膜ではなく「エンドリソソーム」, 「小胞体」で起こる2015

    • Author(s)
      小幡裕希、豊島翔太、若松 英、小川修平、江角浩安、安部 良
    • Publisher
      科学評論社
    • Related Report
      2015 Research-status Report
  • [Book] 理大 科学フォーラム 「マスト細胞のがん化シグナリングは細胞内小器官で起こる」2015

    • Author(s)
      小幡裕希
    • Publisher
      理大 科学フォーラム
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京理科大学 生命医科学研究所 免疫生物学研究部門

    • URL

      http://tus-ribsjm.clsv.jp/immunology/

    • Related Report
      2016 Research-status Report
  • [Remarks] 東京理科大学 生命医科学研究所 免疫生物学研究部門 安部研究室

    • URL

      http://www.ribs.tus.ac.jp/immunology/

    • Related Report
      2015 Research-status Report
  • [Remarks] 東京理科大学 生命医科学研究所

    • URL

      http://www.ribs.tus.ac.jp

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-16  

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