| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We investigated associations between cancer-specific mutations and phosphorylation motifs. Distributions with these mutations and cancer tissues for these mutations and the evolutionary conservation of each phosphorylation motif were investigated. As a result, it was revealed that the frequency of cancer specific mutagenesis on the phosphorylation motif has a positive correlation with the evolutionary conservation of the motif. This means that in cancer tissues, mutations tend to accumulate in physiologically important phosphorylation motifs, mutations on the phosphorylation motif in the cancer tissue are not random mutations due to genomic instability, suggesting spontaneously selective mutations. This study combining tissue specific gene mutation information with our own phosphorylation motif data is expected to lead to predict the effect on canceration by gene mutation, to functionally unknown phosphorylation sites.
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