| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
In order to target anchorage-independence, which is a majour function of cancer metastasis, as a target of cancer therapy, we aimed to clarify the control mechanism of anchorage-independence by CUB domain-containing protein 1 ( CDCP1). In this study, we revealed that the extracellular CUB2 domain of CDCP1 is involved in the CDCP1 homoohilic complex formation on the cell membrane and is also important for regulating CDCP1 signal via activation of Src family kinase. In addition, we identified two small-molecular compounds effective for suppressing anchorage-independence by blocking CDCP1 signal and succeeded in suppressing metastasis of gastric cancer cells by mouse peritoneal dissemination model.
These results suggest that CDCP1 is useful candidate for cancer therapy targeting anchorage-independence of cancer cells.
|
