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Development of TP53 signature in vitro diagnostics (IVD)

Research Project

Project/Area Number 15K06851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor diagnostics
Research InstitutionTohoku University

Principal Investigator

Takahashi Shin  東北大学, 大学病院, 講師 (20431570)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsバイオマーカー / 遺伝子発現プロファイル / TP53 / 予後予測 / 治療効果予測
Outline of Final Research Achievements

The purpose of this study is to develop a simple in vitro diagnostic kit aiming at clinical application of TP53 signature.
Probe set of TP53 signature for nCounter was created. TP53 signature data was obtained from the early stage breast cancer cohort (n = 174). Univariate and multivariate analysis results revealed that TP53 signature is the most relevant factor to RFS. In addition, comprehensive gene expression analysis was performed, and the prognostic potential of TP53 signature was compared with Mammaprint, Oncotype DX, and PAM 50. It was shown that TP53 signature had the highest prognostic predictability.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer.2018

    • Author(s)
      Yamaguchi S, Takahashi S, Mogushi K, Izumi Y, Nozaki Y, Nomizu T, Kakugawa Y, Ishida T, Ohuchi N, Ishioka C, Kato S.
    • Journal Title

      Oncotarget

      Volume: 9(18) Issue: 18 Pages: 14193-14206

    • DOI

      10.18632/oncotarget.24447

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer2017

    • Author(s)
      Yamaguchi Shigeo、Takahashi Shin、Mogushi Kaoru、Izumi Yuki、Nozaki Yumi、Nomizu Tadashi、Kakugawa Yoichiro、Ishida Takanori、Ohuchi Noriaki、Ishioka Chikashi、Kato Shunsuke
    • Organizer
      European Society of Medical Oncology (ESMO) 2017 Congress, Madrid, Spain
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of TP53 signature diagnostic system using multiplex RT-PCR and observational study to confirm the prognostic value of TP53 signature in breast cancer2017

    • Author(s)
      Shin Takahashi, Takafumi Fukui, Tadashi Nomizu, Yoichiro Kakugawa, Takanori Ishida, Shigeo Yamguchi, Shunsuke Kato, Noriaki Ouchi, Nobuhisa Gondo, Chikashi Ishioka
    • Organizer
      European Society of Medical Oncology (ESMO) 2017 Congress, Madrid, Spain
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of in vitro diagnostics for TP53 signature aiming at optimization of breast cancer treatment2017

    • Author(s)
      Shin Takahashi, Takafumi Fukui, Tadashi Nomizu, Yoichiro Kakugawa, Takanori Ishida, Shigeo Yamguchi, Shunsuke Kato, Noriaki Ouchi, Nobuhisa Gondo, Chikashi Ishioka
    • Organizer
      第15回日本臨床腫瘍学会学術集会 神戸国際会議場(兵庫)
    • Related Report
      2017 Annual Research Report
  • [Presentation] TP53 signatureによる乳がんの予後および治療効果予測2017

    • Author(s)
      高橋信
    • Organizer
      20th BREAST CANCER UP-TO-DATE Meeting
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of in vitro diagnostics for TP53 signature aiming at optimization of breast cancer treatment2016

    • Author(s)
      高橋信、福井 崇史、野水 整、角川 陽一郎、山口 茂夫、加藤 俊介、石岡 千加史
    • Organizer
      第14回日本臨床腫瘍学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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