Development of TP53 signature in vitro diagnostics (IVD)
Project/Area Number |
15K06851
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor diagnostics
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | バイオマーカー / 遺伝子発現プロファイル / TP53 / 予後予測 / 治療効果予測 |
Outline of Final Research Achievements |
The purpose of this study is to develop a simple in vitro diagnostic kit aiming at clinical application of TP53 signature. Probe set of TP53 signature for nCounter was created. TP53 signature data was obtained from the early stage breast cancer cohort (n = 174). Univariate and multivariate analysis results revealed that TP53 signature is the most relevant factor to RFS. In addition, comprehensive gene expression analysis was performed, and the prognostic potential of TP53 signature was compared with Mammaprint, Oncotype DX, and PAM 50. It was shown that TP53 signature had the highest prognostic predictability.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer.2018
Author(s)
Yamaguchi S, Takahashi S, Mogushi K, Izumi Y, Nozaki Y, Nomizu T, Kakugawa Y, Ishida T, Ohuchi N, Ishioka C, Kato S.
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Journal Title
Oncotarget
Volume: 9(18)
Issue: 18
Pages: 14193-14206
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Development of TP53 signature diagnostic system using multiplex RT-PCR and observational study to confirm the prognostic value of TP53 signature in breast cancer2017
Author(s)
Shin Takahashi, Takafumi Fukui, Tadashi Nomizu, Yoichiro Kakugawa, Takanori Ishida, Shigeo Yamguchi, Shunsuke Kato, Noriaki Ouchi, Nobuhisa Gondo, Chikashi Ishioka
Organizer
European Society of Medical Oncology (ESMO) 2017 Congress, Madrid, Spain
Related Report
Int'l Joint Research
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