| Project/Area Number |
15K06856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUKUSHIMA Kiyoyasu 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00746620)
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| Co-Investigator(Kenkyū-buntansha) |
久保 亨 長崎大学, 熱帯医学研究所, 客員研究員 (50444873)
永安 武 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80284686)
松本 桂太郎 長崎大学, 医歯薬学総合研究科(医学系), 講師 (80404268)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 肺腺癌 / がん遺伝子 / 遺伝子変異 / メチル化 |
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| Outline of Final Research Achievements |
We identified a family lineage of possible autosomal dominant familial lung cancer, which has 24 lung cancer pants within three generations.
In order to detect responsible cancer genes, we performed genome-wide analysis for three lung cancer patients and six cancer-free individuals within the family. Initially we selected 17 gene mutations by linkage-exome approach. And then by mutation-function analysis, five candidate gene mutations were identified.Now we are verifying mutations in those five genes are responsible for this familial hereditary lung cancer.
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