Evaluation of tumor heterogeneity by deep tumor imaging and control of drug delivery system

• Project/Area Number: 15K06871
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
• Principal Investigator: Toh Kazuko 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (90342732)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 腫瘍深部イメージング / ドラッグデリバリーシステム

Outline of Final Research Achievements

Tumor heterogeneity leads to difficulties in treatment. Especially, drugs are hard to reach in hypoxic regions away from blood vessels, and that will cause recurrence. In this study, we aimed to develop the carriers for drug delivery system (DDS) that reaches the deeper part of the tumor. After preparation of subcutaneous tumor model of pancreatic cancer, tumor accumulation of various DDS carriers were compared by multiphoton microscope. The polyion complex (PICs), obtained by the self-assembly of the block copolymer and nucleic acid, delivered the siRNA to the center of the BxPC3 tumor nest most. By optimizing the polymer structure of PICs, tumor accumulation of siRNA was enhanced 1.8 times.