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inhibition of cancer progression by regulation of amino acid transporters

Research Project

Project/Area Number 15K06879
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor therapeutics
Research InstitutionKyorin University

Principal Investigator

Kimura Toru  杏林大学, 医学部, 学内講師 (30433725)

Research Collaborator ENDOU Hitoshi  杏林大学, 医学部, 名誉教授
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsトランスポーター / 癌 / アミノ酸
Outline of Final Research Achievements

Amino acids are essential for our body. Some of the amino acids have a role for signaling molecules and are involved in various reaction in our body. Amino acid transporters has an ability to regulate amino acid gradient across membrane. In this study, we examined amino acid transporters related with cancer progression.
We focused on transporters that transport leucine and arginine important for cell growth and NO production. It was suggested that LAT1 is the most important transporter in cancer growth. We also searched and investigated regulators of LAT1 transporter. We found molecular chaperone and one of the protein related with protein degradation pathway for LAT1 interacting proteins.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters.2017

    • Author(s)
      Otsuki H, Kimura T, Yamaga T, Kosaka T, Suehiro JI, Sakurai H.
    • Journal Title

      Prostate.

      Volume: 77 Issue: 2 Pages: 222-233

    • DOI

      10.1002/pros.23263

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of epithelial-mesenchymal transition by cetuximab via the EGFR-GEP100-Arf6-AMAP1 pathway in head and neck cancer.2017

    • Author(s)
      Matsumoto Y, Sakurai H, Kogashiwa Y, Kimura T, Matsumoto Y, Shionome T, Asano M, Saito K, Kohno N.
    • Journal Title

      Head Neck.

      Volume: 39 Issue: 3 Pages: 476-485

    • DOI

      10.1002/hed.24626

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells2015

    • Author(s)
      Xu M, Sakamoto S, Matsushima J, Kimura T, Ueda T, Mizokami A, Kanai Y, Ichikawa T.
    • Journal Title

      J Urol

      Volume: 195 Issue: 5 Pages: 1588-1597

    • DOI

      10.1016/j.juro.2015.11.071

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 前立腺癌アンドロゲン受容体高発現細胞株におけるロイシン輸送トランスポータ2015

    • Author(s)
      大槻英男、木村 徹、山賀 貴、末弘淳一、櫻井裕之
    • Organizer
      第 132 回日本薬理学会関東部会
    • Place of Presentation
      浦安
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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