| Project/Area Number |
15K06899
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | Kyushu University |
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Principal Investigator |
Toh Hidehiro 九州大学, 生体防御医学研究所, 特任講師 (10353468)
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| Co-Investigator(Renkei-kenkyūsha) |
MIURA Kyoko 熊本大学, 大学院生命科学研究部, 准教授 (80583062)
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| Research Collaborator |
MORITA Hidetoshi 岡山大学, 環境生命科学研究科, 教授 (70257294)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ハダカデバネズミ / エピジェネティクス / DNAメチル化 / メチローム / 全ゲノムバイサルファイト解析 / 真社会性 / 女王化 / エピゲノム / 次世代シークエンサー |
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| Outline of Final Research Achievements |
The naked mole rats (Heterocephalus glaber) are exceptionally long-lived, cancer-resistant rodents, and have a eusocial colony structure. In this study, we focused on DNA methylation, an epigenetic mechanism, and investigated whether DNA methylation has contributed to the evolution of the naked mole rat’s extraordinary traits. Using amplification-free whole-genome bisulfite sequencing, we constructed the base-resolution methylome maps of naked mole rat’s uterus, ovary, and oviduct. Moreover, we compared the uterus methylomes of naked mole rats and laboratory mouse. Thus, our results provide a basis for understanding the mechanisms and significance of DNA methylation in naked mole rat’s cells.
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