| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Defenseless signaling is the true nature of the cancer cell. By using RISC-capture assay for normal and clinical samples, this study demonstrates that the signaling cascade habitually confronts epigenetic interference composed of miRNA group in human cells. In malignant lymphoma cells, aberrant action of epigenetic factors hierarchically influences the functional miRNA en masse, enhancing target gene translation and coherent active crosstalk involving NF-kB, Ras-Erk, and Akt-mTOR. We illustrate an example of a biological masterplan comprised of signaling networks, miRNAs, translation regulation, and epigenetic mechanisms. Furthermore, we show that appropriate inhibition of the signaling cascades or the epigenetic abnormality appear to be effective for malignant lymphoma.
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