Genetically modified virus therapy targeting HTLV-1, a carcinogenic virus
| Project/Area Number |
15K06911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | Kagoshima University |
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Principal Investigator |
Suzuki Shinsuke 鹿児島大学, 医歯学総合研究科, 特任講師 (20437974)
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| Co-Investigator(Renkei-kenkyūsha) |
KOSAI Kenichirou 鹿児島大学, 大学院医歯学総合研究科先進治療科学専攻 運動機能修復学講座遺伝子治療・再生医学分野, 教授 (90258418)
UENO Shinichi 鹿児島大学, 大学院医歯学総合研究科先進治療科学専攻臨床腫瘍学講座, 特任講師 (40322317)
魚住 公治 独立行政法人国立病院機構, 鹿児島医療 センター(臨床研究部), 腫瘍内科部長 (90253864)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 成人T細胞性白血病 / 特異的増殖型アデノウイルス / HTLV-1 bZIP factor / 成人 T 細胞性白血病 / HTLV-1 bZIP factor遺伝子 / ゲノム創薬 / ヒトT細胞白血病ウィルスI型 / 特異的増殖型アデノウィルス / ヒトT細胞白血病ウイルスI型 |
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| Outline of Final Research Achievements |
We aimed to establish a novel treatment by conditionally replicating adenovirus (CRA) targeted to human T cell leukemia virus type I (HTLV-1). HTLV-1 is a causative virus of adult T-cell leukemia (ATL). We reconfirmed that the HTLV-1 bZIP factor (HBZ) gene is expressed in HTLV-1 infected cells. We are developing HBZ promoter-dependent CRA (HBZ.CRA) that erades only HTLV-1 infected cells.
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Report
(4 results)
Research Products
(1 results)
