Epidemiological and experimental analyses of arsenic exposure to epigenome of human embryos and child
Project/Area Number |
15K06912
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical genome science
|
Research Institution | Jichi Medical University |
Principal Investigator |
Mise Nathan 自治医科大学, 医学部, 講師 (00360644)
|
Research Collaborator |
Fatmi Zafar Aga Khan大学, 教授
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 無機ヒ素暴露 / DNAメチル化 / エピジェネティクス / 胚発生 / 無機ヒ素 / 胎児期曝露 / ヒ素 / 胎盤 / 胚性幹細胞 |
Outline of Final Research Achievements |
Intake of inorganic arsenic causes various adverse effects through alteration of methylation of genomic DNA. We collected food duplicate samples and genomic DNA samples of children and pregnant women from inorganic arsenic contaminated areas of Pakistan to determine the levels of inorganic arsenic intake and effects on DNA methylation. We have found that the methylation of the promoter regions of lung cancer-related genes, HOXB5, HOXB9, POLD4, and MSX1 were lower in higher arsenic exposed group than in lower exposed group. These results indicate that exposure to inorganic arsenic affects to health of children and pregnant women through aberrant DNA methylation due to competition of general methyl-donor.
|
Report
(4 results)
Research Products
(11 results)
-
-
-
-
-
-
-
-
[Journal Article] Heavy metal exposure, in combination with physical activity and aging, is related with oxidative stress in Japanese women from a rural agricultural community2016
Author(s)
Cui, X. Ohtsu, M. Mise, N. Ikegami, A. Mizuno, A. Sakamoto, T. Ogawa, M. Machida, M. Kayama, F.
-
Journal Title
Springerplus
Volume: 5巻
Issue: 1
Pages: 885-885
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] External lead contamination of women's nails by surma in Pakistan: Is the biomarker reliable?2016
Author(s)
Ikegami, A. Takagi, M. Fatmi, Z. Kobayashi, Y. Ohtsu, M. Cui, X. Mise, N. Mizuno, A. Sahito, A. Khoso, A. Kayama, F.
-
Journal Title
Environmental Pollution
Volume: 218巻
Pages: 723-727
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Exposure assessment of lead from food and airborne dusts and biomonitoring in pregnant mothers, their fetus and siblings in Karachi, Pakistan and Shimotsuke, Japan.2016
Author(s)
Kayama F, Fatmi Z, Ikegami A, Mizuno A, Ohtsu M, Mise N, Cui X, Ogawa M, Sakamoto T, Nakagi Y, Yoshida T, Sahito A, Naeem S, Ghias K, Zuberi H, Tariq K, Kobayashi Y, Nohara K.
-
Journal Title
Rev. Environ. Health.
Volume: 31(1)
Issue: 1
Pages: 33-35
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-