structural and functional analyses of novel lectins from marine invertebrates, and its application.
| Project/Area Number |
15K06977
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
UNNO Hideaki 長崎大学, 工学研究科, 助教 (10452872)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | X線結晶構造解析 / レクチン / Crassostrea gigas / Gyractis japonica / Saxidomus purpurata / 糖鎖マイクロアレイ / 等温滴定型熱量測定 / SPL-a/b / C-type / GJL1 / SPL1 / 結晶構造解析 / CGL1 / 糖鎖 / 糖特異性 / 等温滴定型カロリメトリー / フロンタル・アフィテニティクロマトグラフィー |
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| Outline of Final Research Achievements |
Structural and functional analyses of novel lectins, CGL1 from Crassostrea gigas, GJL-1 from Gyractis japonica, and SPL-a/b from Saxidomus purpurata, were enforced. Structural analysis of CGL1 revealed its unique fold and binding pattern that have not been confirmed in known lectin families. GJL-1 and SPL-a/b also show unique characteristics as a result of the analyses.
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Report
(4 results)
Research Products
(24 results)
