| Project/Area Number |
15K06989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
TSUBOI Shigeru 弘前大学, 医学研究科, 客員研究員 (20526727)
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| Co-Investigator(Kenkyū-buntansha) |
大山 力 弘前大学, 医学研究科, 教授 (80282135)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKIZAKI Ikuko 弘前大学, 大学院医学研究科, 准教授 (80302024)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腫瘍免疫 / 細胞傷害性Tリンパ球 / 膀胱癌 / 転移 / 細胞傷害性Tリンパ球(CTL) / リンパ節転移 / O-グリカン |
|---|
| Outline of Final Research Achievements |
We have tumor immunity to suppress cancer cell proliferation and metastasis.However, cancer exerts the versatile immune evasion strategies to predominate over tumor immunity. A series of our studies revealed that bladder cancer cells evade each tumor immune system by different evasion strategies using altered glycosylation. A glycosyltransferase, C2GnT forms a branched structure called core 2 O-glycans on cell-surface glycoproteins. To elucidate the roles of core 2 O-glycans in bladder cancer metastasis, we analyzed C2GnT expression in lymph node, a target organ. We showed that bladder cancer cells evade tumor immune system by cytotoxic T lymphocyte (CTL) by downregulating C2GnT expression. C2GnT-negative cancer cells evade CTL attack, resulting in indefinite proliferation in lymph node.
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