Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Outline of Final Research Achievements |
Directed cell migration is important for various cellular processes including immune response, tissue development and tissue repair. However, the underlying mechanisms are still not fully understood. In this study, we examined the roles of the PI3K-Akt pathway in the regulation of microtubule dynamics and found Akt1 can phosphorylate EB2/RP1, a member of EB family microtubule associated proteins. We are now trying to understand the molecular mechanisms by which EB2/RP1 regulates microtubule dynamics and the relationships between Akt1 and EB2/RP1.
|