| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
Mannose trimming in the endoplasmic reticulum required for glycoprotein degradation is carried out by the EDEM family proteins (EDEM 1/2/3). In this study, we clarified the functional significance of EDEM2 in the mannose trimming reaction and identified three cysteine residues essential for the mannosidase activity of EDEM2. We also identified an candidate for the partner protein of EDEM2. In addition, we found that severely misfolded glycoproteins are forcibly degraded even in the absence of EDEM-mediated mannose trimming.
|
