| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Intrinsically disordered proteins (IDPs) have disordered structures under physiological conditions but fold into specific structures upon binding to their target proteins. Because many eukaryotic proteins are IDPs, it is important to elucidate the determinants of the mechanisms of coupled folding and binding of IDPs and to unify the understanding of how IDPs recognize their target molecules. Here, we showed that even a single IDP can contain two regions that bind their targets via different binding mechanisms, including the induced-fit and conformational selection mechanisms. Moreover, our results suggest that the folding ability of IDPs determines their binding mechanisms.
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