PI4P production and its physiological role at the plasma membrane
| Project/Area Number |
15K07042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | イノシトールリン脂質 |
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| Outline of Final Research Achievements |
Phosphatidylinositol 4-phosphate (PI4P), a phosphoinositide enriched in the plasma membrane, has been shown to serve as a precursor for phosphatidylinositol 4,5-bisphosphate. However, its own role at the plasma membrane has been poorly understood. We found that PI4KIIIα, the kinase responsible for the production of PI4P at the plasma membrane, forms a complex with TMEM150A, and localizes at the plasma membrane in many types of cells. Furthermore, PI4P produced by the PI4KIIIα complex recruits ORP5 and ORP8, members of the oxysterol-binding protein-related protein family, at the contact sites between the plasma membrane and endoplasmic reticulum.
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Report
(4 results)
Research Products
(17 results)
