| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Cell migration contributes to a variety of diseases including tumor metastasis. It is important to elucidate molecular mechanisms underlying the regulation of cell migration to provide new therapeutic targets. In this study, we focused on the interaction between ligand-independent EphA2 receptor signaling and growth factor signaling, both of which play key roles in regulation of cell migration. We found that 1) hepatocyte growth factor (HGF) induces activation of EphA2 during epithelial-mesenchymal transition in epithelial cells, 2) SGEF activity is regulated by its tyrosine phosphorylation, 3) EphA2 is phosphorylated and activated by RSK in response to epidermal growth factor stimulation in glioblastoma cells.
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