Structural and functional analysis of cell networks within taste buds.
| Project/Area Number |
15K07053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
Ohtubo Yoshitaka 九州工業大学, 大学院生命体工学研究科, 准教授 (00380725)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 傍分泌 / ヘミチャネル / アセチルコリン受容体 / ATP受容体 / 電位依存性Kチャネル / パッチクランプ法 / 細胞間情報伝達 / 味神経線維 / 電位依存性Ｋチャネル / 遺伝子サブタイプ / 細胞型 / 神経線維 / 味蕾構造 / パッチクランプ |
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| Outline of Final Research Achievements |
Taste buds consist of the heterogeneous population of taste bud cells with different cell types that may make cell-to-cell communications within taste buds. I show that the electrophysiological properties of ion channels for paracrine signaling, the cell-type dependent expression of the channel and neurotransmitter receptors, and the ratio of cell types expressing the channel and receptors in a single taste bud. The discussion is made on the role of these channels and receptors in the transmission of taste responses.
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Report
(4 results)
Research Products
(9 results)
