| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
ADAMs is a matrix-type protease and in involved in various life phenomena in higher organisms. The fission yeast S. pombe is the simplest organism which possesses ADAM (Mde10). Mde10 is responsible for construction of the characteristic structure of the spore surface (spike structure). In this study, we constructed various deletion mutants of Mde10 and addressed the interesting feature. i) Neither protease domain nor disintegrin domain was required for the function of Mde10. ii) The transmembrane domain was important for the formation of the spike structure. Furthermore, we identified two novel proteins (a fasciclin-domain protein and an alpha-amylase domain protein) involved in the spike formation.
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