| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Autophagy is known to participate in the condition of a patient of various diseases including cancer in addition to the role as the bulk degradation and the recycling system of the unnecessary protein at the time of the starvation. In this study, I paid my attention to the MAP1LC3 gene family which participated in autophagy and elucidated one end of the influence that epigenetic control in the human uterine cervix cancer cell strain gave to expression. In addition, I paid my attention to transcription factor CHOP which participated in endoplasmic reticulum stress and analyzed the CHOP responsive element in ULK1 and the ULK2 gene promoter.
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