Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Outline of Final Research Achievements |
During the course of the genome-wide screening, we found that E. coli dedD gene is essential for the maintenance of cell division under alkaline growth condition. The cell division deficiency of the dedD deletion strain was not dependent of the presence of SOS and NO pathway, and the localization of FtsN in this strain was perturbed under alkaline condition. The BACTH assay indicated potential interactions between DedD and several other divisome proteins. These results suggested that DedD might act as a scaffold that would keep maintaining proper assembly of divisome components under alkaline condition.
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