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Characterization of novel mechanisms that maintain bacterial cell division under alkaline condition.

Research Project

Project/Area Number 15K07061
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cell biology
Research InstitutionNigata University of Phermacy and Applied Life Sciences

Principal Investigator

Yamaguchi Toshio  新潟薬科大学, 薬学部, 准教授 (50434452)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
KeywordsDedD / 細胞分裂 / 大腸菌 / アルカリ耐性 / divisome / 細菌 / ストレス耐性
Outline of Final Research Achievements

During the course of the genome-wide screening, we found that E. coli dedD gene is essential for the maintenance of cell division under alkaline growth condition. The cell division deficiency of the dedD deletion strain was not dependent of the presence of SOS and NO pathway, and the localization of FtsN in this strain was perturbed under alkaline condition. The BACTH assay indicated potential interactions between DedD and several other divisome proteins. These results suggested that DedD might act as a scaffold that would keep maintaining proper assembly of divisome components under alkaline condition.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] 大腸菌DedD蛋白質ペリプラズム領域のストレス条件下における機能解析2017

    • Author(s)
      山口利男、渡辺郁香、竹内洋介、福原正博
    • Organizer
      第90回 日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 大腸菌のアルカリ条件下における新規細胞分裂維持機構の解析2016

    • Author(s)
      山口利男、橋本 充、本田 貴、山本 永、福原正博
    • Organizer
      第89回 日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府天王寺区)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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