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Cellular function of moyamoya disease-associated protein mysterin

Research Project

Project/Area Number 15K07062
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cell biology
Research InstitutionKyoto Sangyo University

Principal Investigator

MORITO Daisuke  京都産業大学, タンパク質動態研究所, 主任研究員 (20514251)

Research Collaborator NAGATA Kazuhiro  
KOTANI Yuri  
SUGIHARA Munechika  
AINUKI Shiori  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsミステリン / モヤモヤ病 / 脂肪滴 / AAA+ / ユビキチン
Outline of Final Research Achievements

Moyamoya disease is a cerebrovascular disorder mostly observed in East Asian countries. It shows progressive stenosis and occlusion at internal carotid arteries, resulting in ischemia and cerebral infarction. Moreover, collateral vessels often rupture, resulting in patient death. We isolated mysterin gene, which was strongly associated with the onset of moyamoya disease; however, its function remained unknown. We recently succeeded in demonstrating that mysterin serves as a regulator of lipid metabolism with tissue culture cell system, for the first time.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2015

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor2017

    • Author(s)
      Kotani Y, Morito D, Sakata K, Ainuki S, Sugihara M, Hatta T, Iemura SI, Takashima S, Natsume T, Nagata K
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 44293-44293

    • DOI

      10.1038/srep44293

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular Biology of Mysterin/RNF2132017

    • Author(s)
      Morito D, Nagata K.
    • Journal Title

      Current Topics in Environmental Health and Preventive Medicine

      Volume: 2 Pages: 45-57

    • DOI

      10.1007/978-981-10-2711-6_4

    • ISBN
      9789811027109, 9789811027116
    • Related Report
      2016 Research-status Report
  • [Journal Article] Physiological Role of Mysterin/RNF213 in Zebrafish2017

    • Author(s)
      Morito D, Nagata K
    • Journal Title

      Current Topics in Environmental Health and Preventive Medicine

      Volume: 2 Pages: 59-67

    • DOI

      10.1007/978-981-10-2711-6_5

    • ISBN
      9789811027109, 9789811027116
    • Related Report
      2016 Research-status Report
  • [Journal Article] Neuromuscular regulation in zebrafish by a large AAA+ ATPase/ubiquitin ligase, mysterin/RNF213.2015

    • Author(s)
      Kotani Y, Morito D, Yamazaki S, Ogino K, Kawakami K, Takashima S, Hirata H, Nagata K.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16161-16161

    • DOI

      10.1038/srep16161

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic Hijacking of ER-Associated Degradation: Is ERAD Flexible?2015

    • Author(s)
      Morito D, Nagata K.
    • Journal Title

      Molecular Cell

      Volume: 59 Issue: 3 Pages: 335-44

    • DOI

      10.1016/j.molcel.2015.06.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.2015

    • Author(s)
      Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI.
    • Journal Title

      The EMBO Journal

      Volume: 34 Issue: 18 Pages: 2334-49

    • DOI

      10.15252/embj.201591711

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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