Cellular function of moyamoya disease-associated protein mysterin
Project/Area Number |
15K07062
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Kyoto Sangyo University |
Principal Investigator |
MORITO Daisuke 京都産業大学, タンパク質動態研究所, 主任研究員 (20514251)
|
Research Collaborator |
NAGATA Kazuhiro
KOTANI Yuri
SUGIHARA Munechika
AINUKI Shiori
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ミステリン / モヤモヤ病 / 脂肪滴 / AAA+ / ユビキチン |
Outline of Final Research Achievements |
Moyamoya disease is a cerebrovascular disorder mostly observed in East Asian countries. It shows progressive stenosis and occlusion at internal carotid arteries, resulting in ischemia and cerebral infarction. Moreover, collateral vessels often rupture, resulting in patient death. We isolated mysterin gene, which was strongly associated with the onset of moyamoya disease; however, its function remained unknown. We recently succeeded in demonstrating that mysterin serves as a regulator of lipid metabolism with tissue culture cell system, for the first time.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor2017
Author(s)
Kotani Y, Morito D, Sakata K, Ainuki S, Sugihara M, Hatta T, Iemura SI, Takashima S, Natsume T, Nagata K
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 44293-44293
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.2015
Author(s)
Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI.
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Journal Title
The EMBO Journal
Volume: 34
Issue: 18
Pages: 2334-49
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research