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The role of the nucleocytoplasmic transport during embryogenesis

Research Project

Project/Area Number 15K07069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cell biology
Research InstitutionNihon University (2016-2017)
National Institutes of Biomedical Innovation, Health and Nutrition (2015)

Principal Investigator

YASUHARA Noriko  日本大学, 文理学部, 准教授 (90423152)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords核輸送 / 核―細胞質間輸送因子 / 分化 / 核―細胞質間蛋白質輸送 / 輸送因子 / 胚発生
Outline of Final Research Achievements

Although the nucleocytoplasmic transport is supposed to be involved in mammalian embryogenesis, not all of the molecular mechanism has been elucidated. We tried to investigate the role of the nucleocytoplasmic transport in mouse embryogenesis via phenotype analysis of transgenic mice. As a result, we found that the transgenic mice exhibited some stage specific phenotype during development. We also tried to characterize the transgenic cell lines of nucleocytoplasmic transport receptors, and revealed that the receptors are involved in proliferation. Additionally, we obtained aptamers that bind specifically to nucleocytoplasmic transport receptor, by which we are planning to use as specific inhibitor when monitoring the activity of the receptors during embryogenesis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Importins in the maintenance and lineage commitment of ES cells2017

    • Author(s)
      NorikoYasuhara, YoshihiroYoneda
    • Journal Title

      Neurochemistry International

      Volume: 105 Pages: 32-41

    • DOI

      10.1016/j.neuint.2017.01.020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport.2017

    • Author(s)
      Noriko Yasuhara, Penmetcha Kumar
    • Journal Title

      Journal of Biochemistry

      Volume: 160 Issue: 5 Pages: 259-268

    • DOI

      10.1093/jb/mvw032

    • NAID

      40021012758

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 細胞増殖における核輸送因子の働き2017

    • Author(s)
      浅野僚二、安原徳子、柴崎典子、地引和也、石畑雄太郎、海江田愛奈美
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ER陽性乳がん細胞における核輸送受容体importinα2の働き2017

    • Author(s)
      地引和也、山本達郎、中尾光善、斉藤典子、安原徳子
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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