| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Although the nucleocytoplasmic transport is supposed to be involved in mammalian embryogenesis, not all of the molecular mechanism has been elucidated. We tried to investigate the role of the nucleocytoplasmic transport in mouse embryogenesis via phenotype analysis of transgenic mice. As a result, we found that the transgenic mice exhibited some stage specific phenotype during development. We also tried to characterize the transgenic cell lines of nucleocytoplasmic transport receptors, and revealed that the receptors are involved in proliferation. Additionally, we obtained aptamers that bind specifically to nucleocytoplasmic transport receptor, by which we are planning to use as specific inhibitor when monitoring the activity of the receptors during embryogenesis.
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