Analysis of gene co-option mechanisms involving epigenetic regulation
| Project/Area Number |
15K07082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Hiroshima University (2017)
Nagahama Institute of Bio-Science and Technology (2015-2016) |
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Principal Investigator |
OGINO Hajime 広島大学, 両生類研究センター, 教授 (10273856)
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| Co-Investigator(Renkei-kenkyūsha) |
WADA Shuichi 長浜バイオ大学, バイオサイエンス学部, 准教授 (20378607)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 発生 / 進化 / 感覚器プラコード / 神経堤 / エピジェネティック制御 / ツメガエル / ナメクジウオ / 遺伝子転用 |
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| Outline of Final Research Achievements |
Jmjd3 is the histone H3 demethylase that was acquired in the vertebrate ancestor by an ancient genome duplication event. In this study, we attempted to reveal the evolutionary mechanisms of neural crest and sensory placode by studying gene regulatory networks activated by the Jmjd3. Our search for the downstream genes of Jmjd3 identified not only genes that are involved in neural crest and/or sensory placode formation (noggin, phox2, etc.) but also a variety of chromatin modifiers including the histone acetyltransferase, kat5. We also performed the enhancer analysis of Amphioxus hedgehog gene, which suggested that the vertebrate ortholog, Ihh, innovated the neural crest / branchial arch enhancer by modifying the ancestral pharyngeal endoderm enhancer during the evolution.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Conservatism and variability of gene expression profiles among homeologous transcription factors in Xenopus laevis.2017
Author(s)
Watanabe, M., Yasuoka, Y., Mawaribuchi, S., Kuretani, A., Ito, M., Kondo, M., Ochi, H., Ogino, H., Fukui, A., Taira, M. and Kinoshita, T.
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Journal Title
Dev. Biol.
Volume: 426
Issue: 2
Pages: 301-324
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Epigenetic modification maintains intrinsic limb-cell identity in Xenopus limb bud regeneration.2015
Author(s)
Hayashi, S., Kawaguchi, A., Uchiyama, I., Kawasumi-Kita, A., Kobayashi, T., Nishide, H., Tsutsumi, R., Tsuru, K., Inoue, T., Ogino, H., Agata, K., Tamura, K. and *Yokoyama, H.
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Journal Title
Dev. Biol.
Volume: 406
Issue: 2
Pages: 271-282
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] The hypomorphic mutations hidden in the allotetraploid genome of Xenopus laevis.2017
Author(s)
Tanouchi, M., Ochi, H., Kawaguchi, A., Igawa, T., Iwata, Y., Sakagami, K. and *Ogino, H.
Organizer
International Symposium at Hiroshima University: Amphibian development, regeneration, evolution and beyond
Related Report
Int'l Joint Research
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[Presentation] Modification of cell differentiation competence by histone H3K27 demethylases and their involvement in tissue regeneration in Xenopus.2016
Author(s)
*Ogino, H., Sudou, N., Kawaguchi, A., Ochi, H., Kamiguchi, S. and Kasahara, H.
Organizer
The joint meeting of the 22nd international congress of zoology & the 87th meeting of the zoological society of Japan, symposium “Regeneration in Zoology”
Place of Presentation
沖縄科学技術大学院大学, 沖縄県国頭郡恩納村
Year and Date
2016-11-15
Related Report
Int'l Joint Research / Invited
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