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Molecular evolution of strigolactone signaling in the parasitic plant Striga hermonthica

Research Project

Project/Area Number 15K07102
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plant molecular biology/Plant physiology
Research InstitutionNagoya University

Principal Investigator

Tsuchiya Yuichiro  名古屋大学, トランスフォーマティブ生命分子研究所, 特任准教授 (00442989)

Research Collaborator McCourt Peter  
Duncan Holbrook-Smith  
TOH Shigeo  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsストリゴラクトン / シグナル伝達 / 寄生植物 / ストライガ / 植物ホルモン / 受容体 / ケミカルバイオロジー
Outline of Final Research Achievements

Strigolactones (SLs) function as plant hormone that regulate various developmental processes including suppression of shoot branching. On the other hands, seed germination of a parasitic plant Striga hermonthica is stimulated by SLs exuded by host roots. In this study, we investigated the relationship between these two functions based on the genetic interaction of HYPOSENSITIVE TO LIGHT/KARRIKIN INSENSITIVE2 ( HTL/KAI2)-mediated SL signaling pathway and light signaling pathway in Arabidopsis. We showed that HTL/KAI2 interact with SUPPRESSOR OF PHYA1 (SPA1), a negative regulator of light signaling, in SL-dependent manner, and this interaction lead SPA1 protein to degradation in planta. We transferred the knowledge to Striga with the discovery of small molecule antagonist of HTL/KAI2 that also inhibit SL-dependent germination of Striga. These results suggest that the evolution of SL pathway took place with its interaction with light signaling pathway in the parasitic plant.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results) Presentation (3 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Toronto(Canada)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Department of Cell and Systems Biology/University of Toronto(Canada)

    • Related Report
      2015 Research-status Report
  • [Journal Article] The dynamics of strigolactone perception in Striga hermonthica: a working hypothesis2018

    • Author(s)
      Tsuchiya Yuichiro、Yoshimura Masahiko、Hagihara Shinya
    • Journal Title

      Journal of Experimental Botany

      Volume: 69 Issue: 9 Pages: 2281-2290

    • DOI

      10.1093/jxb/ery061

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small-molecule antagonists of germination of the parasitic plant Striga hermonthica.2016

    • Author(s)
      Holbrook-Smith D, Toh S, Tsuchiya Y, McCourt P
    • Journal Title

      Nature Chemical Biology

      Volume: 12 Issue: 9 Pages: 724-729

    • DOI

      10.1038/nchembio.2129

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Probing strigolactone receptors in Striga hermonthica with fluorescence.2015

    • Author(s)
      Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
    • Journal Title

      Science

      Volume: 349 Issue: 6250 Pages: 864-869

    • DOI

      10.1126/science.aab3831

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure-function analysis identifies highly sensitive strigolactone receptors in Striga.2015

    • Author(s)
      Toh, S., Holbrook-Smith, D., Stogios, P.J., Onopriyenko, O., Lumba, S., Tsuchiya, Y., Savchenko, A., and McCourt, P.
    • Journal Title

      Science

      Volume: 350 Issue: 6257 Pages: 203-207

    • DOI

      10.1126/science.aac9476

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Probing strigolactone receptors in Striga hermonthica with fluorescence.2017

    • Author(s)
      Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
    • Organizer
      2nd Edition of the International Congress on Strigolactones
    • Place of Presentation
      Trino, Italy
    • Year and Date
      2017-03-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A synthetic stimulant for seed germination in a parasitic plant Striga2017

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      植物生理学会年会
    • Place of Presentation
      鹿児島
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Probing strigolactone receptors in Striga hermonthica with fluorescence.2016

    • Author(s)
      Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
    • Organizer
      The International Plant Growth Substances Association Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-06-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] サイエンスネット2017

    • Author(s)
      土屋 雄一朗
    • Total Pages
      4
    • Publisher
      数研出版
    • Related Report
      2017 Annual Research Report
  • [Remarks] アフリカの食糧問題に希望の光 ~ 寄生植物の発芽を制御するタンパク質を発見 ~

    • URL

      http://www.itbm.nagoya-u.ac.jp/ja/research/2015/08/Yoshimulactone-Striga.php

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 蛍光プローブ、及びそれを用いたストライガ発芽調節物質のスクリーニング方法2015

    • Inventor(s)
      萩原伸也、土屋雄一朗、吉村柾彦、伊丹健一郎、木下俊則
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-132707
    • Filing Date
      2015-07-01
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] ストライガ発芽調節剤2015

    • Inventor(s)
      土屋雄一朗、他
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-132413
    • Filing Date
      2015-07-01
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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