Identification of sex-inducing substances that can trigger the switching from asexual to sexual reproduction in planarians.
| Project/Area Number |
15K07121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO KIMITOSHI 弘前大学, 農学生命科学部, 准教授 (50361465)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | プラナリア / 生殖様式 / 生殖細胞 / 有性化因子 / 生殖様式転換 |
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| Outline of Final Research Achievements |
We tried to identify “sex-inducing substances” that can switch from an asexual to a sexual state in the planarian Dugesia ryukyuensis. The administration of the sex-inducing substances induces the differentiation of ovaries, yolk glands, testes and a copulatory apparatus in turn from the pluripotent stem cells called neoblasts. In the previous study, we identified tryptophan as a sex-inducing substance (an ovary-inducing substance), which is contained in a large amount in the yolk glands. This finding led us to focus on low-molecular weight compounds contained in the yolk glands as candidates for the sex-inducing substances. In the present study, we identified 16 ovary-inducing substances including tryptophan and two crucial sex-inducing substances among the candidate compounds narrowed down by metabolomic analysis.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] The identification of D-tryptophan as a bioactive substance for postembryonic ovarian development in the planarian Dugesia ryukyuensis.2017
Author(s)
Kazuya Kobayashi, Takanobu Maezawa, Hiroyuki Tanaka, Hiroyuki Onuki, Yurie Horiguchi, Hiroshi Hirota, Tetsuo Ishida, Kihachiro Horiike, Yasutoshi Agata, Manabu Aoki, Motonori Hoshi, Midori Matsumoto
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Journal Title
Scientific reports
Volume: 7
Issue: 1
Pages: 45175-45175
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 陸生プラナリアの食性の違いから生存戦略を探る2016
Author(s)
剱持遥太郎, 岩本直也, 鈴木凱斗, 田中秀弥, 小林一也, 中村 剛之, 前澤孝信
Organizer
平成28年度日本動物学会中国四国地区三学会合同大会
Place of Presentation
米子コンベンションセンター（鳥取県米子市）
Year and Date
2016-05-14
Related Report
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