| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We tried to identify “sex-inducing substances” that can switch from an asexual to a sexual state in the planarian Dugesia ryukyuensis. The administration of the sex-inducing substances induces the differentiation of ovaries, yolk glands, testes and a copulatory apparatus in turn from the pluripotent stem cells called neoblasts. In the previous study, we identified tryptophan as a sex-inducing substance (an ovary-inducing substance), which is contained in a large amount in the yolk glands. This finding led us to focus on low-molecular weight compounds contained in the yolk glands as candidates for the sex-inducing substances. In the present study, we identified 16 ovary-inducing substances including tryptophan and two crucial sex-inducing substances among the candidate compounds narrowed down by metabolomic analysis.
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